CTLA4 Protein (His tag)

N° du produit ABIN7321017

Détail du produit

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Cobaye

Source: Yeast (Pichia pastoris)

Purification/Conjugué: Cette CTLA4 protéine est marqué à la His tag.

Fonction: Recombinant Cavia porcellus CTLA-4/CD152 Protein (His Tag)

Séquence: Ala37-Asp161

Attributs du produit: Recombinant Cavia porcellus CD152 is produced by our Yeast expression system and the target gene encoding Ala37-Asp161 is expressed with a 6His tag at the C-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Immobilized Mouse B7-1-Fc(Cat: PKSM041366) at 1μg/ml(100 μl/well) can bind Cavia porcellus CTLA-4-His. The ED50 of Cavia porcellus CTLA-4-His is 0.17ug/ml .

Information d'application

Commentaires:

18-40 kDa

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Autre désignation: CTLA-4/CD152 (CTLA4 Produits)

Synonymes: CTLA-4 Protein, CTLA4 Protein, CD152 Protein, Cd152 Protein, Ctla-4 Protein, Ly-56 Protein, CD Protein, CELIAC3 Protein, GRD4 Protein, GSE Protein, IDDM12 Protein, sCTLA4 Protein, cytotoxic T-lymphocyte associated protein 4 Protein, cytotoxic T-lymphocyte-associated protein 4 Protein, CTLA4 Protein, Ctla4 Protein

Sujet:

Background: Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.

Synonym: Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4

Poids moléculaire: 14.1 kDa

UniProt: H0VUB1

Pathways: Cancer Immune Checkpoints