CTLA4 Protéines
(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].
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CTLA4
Origine: Cynomolgus, Macaque rhésus
Hôte: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
CTLA4
Origine: Rat
Hôte: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Func
Active
CTLA4
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Active
CTLA4
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origine: Cynomolgus
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origine: Humain
Hôte: CHO Cells
Recombinant
>98 % (SDS-PAGE)
CTLA4
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origine: Souris
Hôte: NS1 Cells
Recombinant
>98 % (SDS-PAGE)
CTLA4
Origine: Souris
Hôte: NS1 Cells
Recombinant
>98 % (SDS-PAGE)
CTLA4
Origine: Souris
Hôte: Mammalian Cells
Recombinant
Greater than 95 % as determined by SDS-PAGE.
WB, ELISA
CTLA4
Origine: Souris
Hôte: Mammalian Cells
Recombinant
Greater than 95 % as determined by SDS-PAGE.
WB, ELISA
CTLA4
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origine: Souris
Hôte: Mammalian Cells
Recombinant
Greater than 95 % as determined by SDS-PAGE.
WB, ELISA
CTLA4
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
CTLA4
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
>95 % (SDS-PAGE)
Active
CTLA4
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
>95 % (SDS-PAGE)
Active
Dernières publications pour nos CTLA4 Protéines
: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." dans: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." dans: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).
: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." dans: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).
: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." dans: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).
: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." dans: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).
: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." dans: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).
: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." dans: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).
: "PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." dans: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).
: "Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens." dans: Cancer cell, Vol. 33, Issue 6, pp. 1033-1047.e5, (2019) (PubMed).
: "Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes." dans: Frontiers in pharmacology, Vol. 10, pp. 847, (2019) (PubMed).
Pseudonymes pour CTLA4 Protéines
cytotoxic T-lymphocyte associated protein 4 (CTLA4) Protéinescytotoxic T-lymphocyte-associated protein 4 (Ctla4) Protéines
CD Protéines
CD152 Protéines
Cd152 Protéines
CELIAC3 Protéines
CTLA-4 Protéines
Ctla-4 Protéines
CTLA4 Protéines
GRD4 Protéines
GSE Protéines
IDDM12 Protéines
Ly-56 Protéines
sCTLA4 Protéines
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