CTLA4
(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
Type de proteíne
Recombinant
Attributs du protein
AA 37-160
Origine
Cynomolgus, Macaque rhésus
Source
HEK-293 Cells
Purification/Conjugué
Cette CTLA4 protéine est marqué à la Fc Tag.
Séquence
AA 37-160
Attributs du produit
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40 kDa. As a result of glycosylation, the protein migrates as 45-52 kDa under reducing (R) condition, and 90-105 kDa under non-reducing (NR) condition (SDS-PAGE).
CTLA4
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
ELISA, FACS
CTLA4
Origine: Souris
Hôte: Human Cells
Recombinant
> 95 % as determined by SDS-PAGE
Active
Restrictions
For Research Use only
Format
Lyophilized
Buffer
50 mM Tris, 100 mM Glycine, pH 7.5
Conseil sur la manipulation
Please avoid repeated freeze-thaw cycles.
Stock
-20 °C
Stockage commentaire
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Antigène
CTLA4
(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
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Sujet
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.