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Human POT1 Protein expressed in HEK-293 Cells - ABIN2729370
Choi, Lakamp-Hawley, Kolar, Yan, Borgstahl, Ouellette: The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs. dans Biochimie 2015
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loss-of-function mutations in protection of telomeres 1 (POT1) co-segregated with Chronic lymphocytic leukemia.
the study identifies mutations in KRAS and POT1 as novel determinants of outcome after chemoimmunotherapy using chlorambucil and anti-CD20 (Montrer MS4A1 Protéines) treatment.
Lung fibroblasts deficient in Sirt1 (Montrer SIRT1 Protéines) or treated with a selective Sirt1 (Montrer SIRT1 Protéines) inhibitor exhibit increased cellular senescence and decreased TPP1 (Montrer TPP1 Protéines) levels, whereas Sirt1 (Montrer SIRT1 Protéines) overexpression and pharmacological activation protect against CS-induced TPP1 (Montrer TPP1 Protéines) reduction and telomeric DNA damage.
Binding of POT1-TPP1 (Montrer TPP1 Protéines) unfolds telomere secondary structure to assist loading of additional heterodimers.
We found that NEK6 (Montrer NEK6 Protéines)-mediated phosphorylation of TPP1 (Montrer TPP1 Protéines) Ser255 in G2/M phase regulates the association between telomerase activity and TPP1 (Montrer TPP1 Protéines). Furthermore, we found evidence that POT1 negatively regulates TPP1 (Montrer TPP1 Protéines) phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 mutant lacking its OB-fold domains
Coats plus is caused by a defect in POT1/CST (Montrer GAL3ST1 Protéines)-dependent telomere fill-in
Downregulation of Protection of Telomeres 1 expression in myelodysplastic syndromes with 7q deletion.
The conservation between fission yeast Tpz1-Pot1 and human TPP1 (Montrer TPP1 Protéines)-POT1 interactions resulted in mapping a human melanoma-associated (Montrer ZNF654 Protéines) POT1 mutation (A532P) to the TPP1 (Montrer TPP1 Protéines)-POT1 interface.
Missense variant p.R117C is associated with cardiac angiosarcoma in TP-53 (Montrer TP53 Protéines) negative Li-Fraumeni-like families. Mutation carriers show reduced telomere-bound POT1 levels, abnormally long telomeres and increased telomere fragility.
OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs
The tissue expression analysis indicated that the swine POT1 gene is differentially expressed in tissues including muscle, heart, liver, fat, kidney, lung, pancreas and spleen.
The telomere binding protein POT1a inhibits the production of reactive oxygen species, and rejuvenates aged hematopoietic stem cells.
proliferation of cancer cells lacking POT1 is enabled by the attenuation of the ATR kinase pathway.
demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 (Montrer TINF2 Protéines) phenocopy the POT1a,b knockout setting without showing additional phenotypes
The results of this study found telomere uncapping by Pot1a inactivation resulted in an Atm (Montrer ATM Protéines)-dependent loss of cerebellar interneurons and granule neuron precursors in the mouse nervous system. The
shelterin protein TIN2 (Montrer TINF2 Protéines) can protect chromosome ends as a TRF2 (Montrer TERF2 Protéines)-tethered TIN2 (Montrer TINF2 Protéines)/TPP1 (Montrer TPP1 Protéines)/POT1 complex that lacks a physical connection to TRF1 (Montrer TERF1 Protéines)
Simultaneous inactivation of Pot1a and p53 (Montrer TP53 Protéines) resulted in endometrial intraepithelial carcinoma-like lesions in transgenic mice.
Telomere protection by TPP1 (Montrer TPP1 Protéines)/POT1 requires tethering to TIN2 (Montrer TINF2 Protéines).
POT1a degradation resulted in rapid and reversible activation of the ATR pathway in G1 and S/G2 (Montrer STRN3 Protéines).
The ability of mPot1 to unfold the antiparallel tetraplex of the mouse telomeric DNA is required for telomerase-mediated telomere elongation.
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
POT1-like telomere end-binding protein
, protection of telomeres 1 homolog
, protection of telomeres protein 1
, POT1 protection of telomeres 1 homolog
, single-strand telomeric DNA-binding protein
, POT1 protection of telomeres 1 homolog (S. pombe)
, protection of telomeres 1
, protection of telomeres 1 homolog (S. pombe)
, protection of telomeres protein 1-like
, protection of telomeres 1A