DIO3 Produits
(Deiodinase, Iodothyronine, Type III (DIO3))
Catégories
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008].
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Catégories DIO3 en vedette
DIO3 Anticorps
High quality antibodies with extensive validation data.
DIO3 Kits ELISA
Reliable ELISA kits for a wide range of species.
DIO3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
DIO3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (5)
N° du produit
ABIN7436198
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Rat
Application
WB, IHC, IHC (p)
Validations
- (4)
N° du produit
ABIN653482
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (3)
N° du produit
ABIN750883
Quantité
100 μL
Fiche technique
Fiche technique
DIO3 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966309
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966308
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955331
Quantité
96 tests
Fiche technique
Fiche technique
DIO3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1351611
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1777658
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN3081961
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits DIO3
: "Reduced Skeletal Muscle Protein Turnover and Thyroid Hormone Metabolism in Adaptive Thermogenesis That Facilitates Body Fat Recovery During Weight Regain." dans: Frontiers in endocrinology, Vol. 10, pp. 119, (2019) (PubMed).: "Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes." dans: JCI insight, Vol. 4, Issue 18, (2019) (PubMed).
: "A thyroid hormone network exists in synovial fibroblasts of rheumatoid arthritis and osteoarthritis patients." dans: Scientific reports, Vol. 9, Issue 1, pp. 13235, (2019) (PubMed).
: "Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans." dans: Endocrine, Vol. 59, Issue 2, pp. 353-363, (2018) (PubMed).
: "Caloric restriction induces energy-sparing alterations in skeletal muscle contraction, fiber composition and local thyroid hormone metabolism that persist during catch-up fat upon refeeding." dans: Frontiers in physiology, Vol. 6, pp. 254, (2015) (PubMed).
: "Thyroid hormone inactivation in gastrointestinal stromal tumors." dans: The New England journal of medicine, Vol. 370, Issue 14, pp. 1327-34, (2014) (PubMed).
: "Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis." dans: Endocrinology, Vol. 155, Issue 8, pp. 3160-71, (2014) (PubMed).
: "Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis." dans: Endocrinology, Vol. 155, Issue 10, pp. 4061-8, (2014) (PubMed).
: "Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity." dans: The Biochemical journal, Vol. 453, Issue 1, pp. 71-82, (2013) (PubMed).
: "Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 44, pp. 17232-46, (2013) (PubMed).
Synonymes et noms alternatifs relatifs à DIO3
iodothyronine deiodinase 3 (DIO3), deiodinase, iodothyronine, type 3 (dio3), deiodinase, iodothyronine, type III (dio3), deiodinase, iodothyronine type III (Dio3), deiodinase, iodothyronine, type 3 L homeolog (dio3.L), iodothyronine deiodinase 3 (Dio3), 5DIII, D3, DIOIII, dioiii, itdi3, txdi3, TXDI3, XL-15Protein level used designations for DIO3
- type III iodothyronine deiodinase
- Type 3 DI
- Type-III 5'-deiodinase
- type 3 iodothyronine deiodinase
- deiodinase, iodothyronine, type III
- gene 15
- type 3 deiodinase
- iodothyronine 5-deiodinase type III
- 5DIII
- DIOIII
- type 3 DI
- type-III 5'-deiodinase
- deiodinase, iodothyronine, type 3
- iodothyronine deiodinase, placental type
- thyroxine deiodinase type III (selenoprotein)
- type 3 iodothyronine selenodeiodinase
- type-III 5' deiodinase
- iodothyronine deiodinase type III
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