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DISC1 Produits

(Disrupted in Schizophrenia 1 (DISC1))
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Catégories DISC1 en vedette

DISC1 Anticorps

High quality antibodies with extensive validation data.

DISC1 Kits ELISA

Reliable ELISA kits for a wide range of species.

DISC1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

DISC1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (7)
N° du produit ABIN7439720
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IF
Validations
  • (5)
N° du produit ABIN7266799
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC
Validations
  • (3)
N° du produit ABIN7260711
Quantité 200 μL
Fiche technique Fiche technique

DISC1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method
Validations
N° du produit ABIN1129955
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1129954
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1129956
Quantité 96 tests
Fiche technique Fiche technique

DISC1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3092106
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3136109
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7405693
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits DISC1

El-Hassar, Simen, Duque, Patel, Kaczmarek, Arnsten, Yeckel: "Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels." dans: Biological psychiatry, Vol. 76, Issue 6, pp. 476-85, (2014) (PubMed).

Steinecke, Gampe, Valkova, Kaether, Bolz: "Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 2, pp. 738-45, (2012) (PubMed).

Burdick, Kamiya, Hodgkinson, Lencz, DeRosse, Ishizuka, Elashvili, Arai, Goldman, Sawa, Malhotra: "Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding." dans: Human molecular genetics, Vol. 17, Issue 16, pp. 2462-73, (2008) (PubMed).

Taya, Shinoda, Tsuboi, Asaki, Nagai, Hikita, Kuroda, Kuroda, Shimizu, Hirotsune, Iwamatsu, Kaibuchi: "DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 1, pp. 15-26, (2007) (PubMed).

Duan, Chang, Ge, Faulkner, Kim, Kitabatake, Liu, Yang, Jordan, Ma, Liu, Ganesan, Cheng, Ming, Lu, Song: "Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain." dans: Cell, Vol. 130, Issue 6, pp. 1146-58, (2007) (PubMed).

Hayashi, Portaro, Bastos, Guerreiro, Oliveira, Gorrão, Tambourgi, SantAnna, Whiting, Camargo, Konno, Brandon, Camargo: "Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 10, pp. 3828-33, (2005) (PubMed).

Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling." dans: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1187-91, (2005) (PubMed).

Brandon, Handford, Schurov, Rain, Pelling, Duran-Jimeniz, Camargo, Oliver, Beher, Shearman, Whiting: "Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders." dans: Molecular and cellular neurosciences, Vol. 25, Issue 1, pp. 42-55, (2004) (PubMed).

Hodgkinson, Goldman, Jaeger, Persaud, Kane, Lipsky, Malhotra: "Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder." dans: American journal of human genetics, Vol. 75, Issue 5, pp. 862-72, (2004) (PubMed).

Taylor, Devon, Millar, Porteous: "Evolutionary constraints on the Disrupted in Schizophrenia locus." dans: Genomics, Vol. 81, Issue 1, pp. 67-77, (2003) (PubMed).

Synonymes et noms alternatifs relatifs à DISC1

disrupted in schizophrenia 1 (disc1), disrupted in schizophrenia 1 (DISC1), disrupted in schizophrenia 1 protein (LOC100580606), disrupted in schizophrenia 1 (Disc1), C1orf136, DISC1, SCZD9

Protein level used designations for DISC1

  • disrupted in schizophrenia 1 protein
  • disrupted in schizophrenia 1
  • disrupted in schizophrenia 1 homolog
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