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Human Polyclonal SLC19A1 Primary Antibody pour IHC, WB - ABIN2781749
Payton, Liu, Ge, Matherly: Transcriptional regulation of the human reduced folate carrier A1/A2 promoter: Identification of critical roles for the USF and GATA families of transcription factors. dans Biochimica et biophysica acta 2005
Show all 3 Pubmed References
miR-595 acts as a phenotypic regulator of methotrexate sensitivity in CEM/C1 cells by targeting SLC19A1.
RFC, IL15 and VDR germline variants are associated with minimal residual disease in pediatric B-cell precursor ALL
We identified eight novel variants in SLC19A1 and twelve novel variants in FOLR1, FOLR2, and FOLR3. Pathogenic variants include c.1265delG in SLC19A1 resulting in an early stop codon, four large insertion deletion variants in FOLR3, and a stop_gain variant in FOLR3
Reduced SLC19A1 expression in human adipocytes induces DNA hypermethylation, resulting in increased expression of specific proinflammatory genes, including CCL2. This constitutes an epigenetic mechanism that might link dysfunctional adipocytes to white adipose tissue inflammation and Insulin resistance.
data suggested that the RFC1 A80G G allele was an APOE 4-independent risk factor for late-onset Alzheimer's disease (AD
The presence of the genetic polymorphism of RCF1 is a maternal risk factor for Down syndrome in Brazil.
The results of this study suggest that genetic variants of methionine metabolism are associated with meningioma formation
MTHFR 677C/T and RFC1 80G/A polymorphisms may serve as predictors of toxicity during maintenance chemotherapy in childhood acute lymphoblastic leukemia or lymphoma.
Neonatal RFC1 polymorphism influenced total homocysteinein neonates
There was an association between RFC1 A80G variant and the risk of nonsymdromic cleft lip with or without palate.
the A80G polymorphism of reduced folate carrier 1 (RFC1) gene may have a role in head and neck squamous cell carcinoma
the G80A mutation in the RFC1 gene is associated with a greater risk for sporadic breast cancer and oxidative DNA damage
We demonstrated no difference in tHcy, folates, vitamin B12 levels and allelic frequencies of C677T and G80A polymorphisms in MTHFR and RFC genes between obese and no obese Tunisian children.
677T and 1298C alleles of MTHFR and G80 RFC-1 show association with hyperhomocysteinemia.
High RFC1 is associated with adenocarcinoma in non-small-cell lung carcinoma EGFR [corrected] mutation.
Data suggest that genotypes for the MTHFR C677T and RFC rs1051266 polymorphism might be associated with the risk of conotruncal heart defects.
These data suggest a role of the polymorphism G80A in RFC1 in the risk of relapse and the mortality risk in patients with acute lymphoblastic leukemia.
The presence of the mutant MTHFR 1298C and also RFC 80A was linked to a decreased risk of developing chidlhood acute lymphoid leukemia (ALL).
The combined presence of RFC1 mutant alleles and the cystathionine b-synthase homozygous mutant allele was associated with a 4.81-fold increased risk of having a child with Down syndrome (95 % CI 1.82-12.68, P = 0.0007).
Maternal RFC-1 80A>G polymorphism might be associated with an increased risk of having a birth with Down Syndrome. [Meta-analysis]
The mRNAs encoding Folr2 and the intestinal folate transporter Slc46a1 were not detected in 2-cel embryos and blastocysts.
Interleukin-6 regulated the efficacy of methotrexate by decreasing the expression of SLC19A1.
expressed in placenta at highest level during early development
Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
interaction between the E45 and K404 residues in the first and 11th transmembrane domains; the E45 residue appears to be the more dominant determinant of binding and anion sensitivity
First evidence of RFC expression in rapidly dividing cells of developing neural tube, craniofacial region, limb buds and heart duggests that these regions may be particularly susceptible to folate deficiency.
existence of four unique noncoding exons and promoters for mRFC and demonstrate a facile induction of mRNAs for mRFC and multidrug resistance-associated proteins 1 and 3 in intestine in response to changes in dietary folate intake
Inactivation of RFC1 impacts the expression of several ligands and interacting proteins in the cubilin-amnionless-megalin complex that are involved in the maternal-fetal transport of folate and other nutrients.
Intestinal folate uptake process undergoes differentiation-dependent regulation and that this regulation is mediated via changes in the level of expression of both the RFC and PCFT.
The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.
solute carrier family 19 (folate transporter), member 1
, folate transporter 1
, intestinal folate carrier 1
, placental folate transporter
, reduced folate carrier protein
, solute carrier family 19 member 1
, intestinal folate carrier protein
, reduced folate carrier 1
, solute carrier family 19 (sodium/hydrogen exchanger), member 1
, methotrexate carrier 1
, methotrexate carrier 2
, methotrexate carrier 5
, methotrexate carrier 6
, solute carrier family 19, member 1
, 58 kDa hydrophobic protein
, Folate carrier protein
, Methotrexate uptake protein
, Solute carrier family 19 member 1