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anti-Mouse (Murine) GRB7 Anticorps:
anti-Rat (Rattus) GRB7 Anticorps:
anti-Human GRB7 Anticorps:
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Human Polyclonal GRB7 Primary Antibody pour ELISA, WB - ABIN249513
Margolis, Silvennoinen, Comoglio, Roonprapunt, Skolnik, Ullrich, Schlessinger: High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. dans Proceedings of the National Academy of Sciences of the United States of America 1992
GRB7 gene expression in uterus during embryo implantation is regulated by Mmu-miR (Montrer MLXIP Anticorps)-193.
Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR (Montrer EGFR Anticorps)-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.
The adaptor Grb7 links netrin-1 (Montrer NTN1 Anticorps) signaling to regulation of mRNA translation of kappa opioid receptor (Montrer OPRK1 Anticorps).
Grb7 is identified as an integral component of stress granules.
data shows that GRB7 expression in invasive breast cancer correlates with markers of a more aggressive phenotype, including HER2 (Montrer ERBB2 Anticorps) overexpression, a greater degree of HER2 (Montrer ERBB2 Anticorps) amplification, ER negativity, and p53 (Montrer TP53 Anticorps) positivity
The crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with the Grb7-SH2 domain.
Grb7 protein Ras-associating domain oligomerization has been reported.
Study provided a direct link between the signal adapter protein (Montrer TOLLIP Anticorps) Grb7, anti-apoptotic protein Hax1 (Montrer HAX1 Anticorps) isoform 1, and Caspase3-mediated apoptosis pathways, and suggests that besides modulating cell migration and signal transduction, Grb7 may also participate in Hax1 (Montrer HAX1 Anticorps)-related apoptosis pathways mediated by Caspase3.
Suggest close relationship between Grb7 gene amplification and GRB7 protein overexpression in human ovarian cancer. Immunohistochemistry might have limited diagnostic value in these tumors compared to fluorescence in situ hybridization.
Grb7 was found to be significantly related to the biological classification of breast cancer
apo (Montrer C9orf3 Anticorps) Grb7 SH2 domain crystallized in the trigonal space group P63 (Montrer RPE65 Anticorps), whereas the G7-B1-Grb7 SH2 domain complex crystallized in the monoclinic space group P21 (Montrer CDKN1A Anticorps)
The data reveal that Grb7 plays an important role in breast cancer progression, beyond the context of HER2 (Montrer ERBB2 Anticorps)+ve cell types
Grb7 protein interacts with Filamin-a, an actin-crosslinking component of the cell cytoskeleton.
Data suggest that calmodulin controls Grb7-mediated cell migration.
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene.
growth factor receptor-bound protein 7
, growth factor receptor-bound protein 7-like
, GRB7 adapter protein
, Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7)
, epidermal growth factor receptor GRB-7
, growth factor receptor binding protein GRB7