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Aperçu des produits pour anti-GRB7 (GRB7) Anticorps

Full name:: anti-Growth Factor Receptor-Bound Protein 7 Anticorps (GRB7)

Chez www.anticorps-enligne.fr sont 112 Growth Factor Receptor-Bound Protein 7 (GRB7) Anticorps de 23 de différents fournisseurs disponibles. De plus, nous expédions GRB7 Kits (14) et GRB7 Protéines (12) et beaucoup plus de produits pour cette protéine. Un total de 145 GRB7 produits sont actuellement listés.

Synonymes:: GRB7, mKIAA4028

afficher tous les anticorps	Gène	GeneID	UniProt
	GRB7	14786	Q03160
	GRB7	84427	Q9QZC5
	GRB7	2886	Q14451
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anti-GRB7 Anticorps mieux référencés

Human Polyclonal GRB7 Primary Antibody pour ELISA, WB - ABIN249513 : Margolis, Silvennoinen, Comoglio, Roonprapunt, Skolnik, Ullrich, Schlessinger: High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. dans Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
Human Polyclonal GRB7 Primary Antibody pour IHC (p), WB - ABIN5518677 : Zeng, Yang, Hu, Liu, Yang, Ran, Li, Li, Yu: Grb7 gene amplification and protein expression by FISH and IHC in ovarian cancer. dans International journal of clinical and experimental pathology 2016 (PubMed)

Plus d’anticorps contre GRB7 partenaires d’interaction

Mouse (Murine) Growth Factor Receptor-Bound Protein 7 (GRB7) interaction partners

GRB7 gene expression in uterus during embryo implantation is regulated by Mmu-miR-193.
Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.
The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation of kappa opioid receptor.
Grb7 is identified as an integral component of stress granules.

Human Growth Factor Receptor-Bound Protein 7 (GRB7) interaction partners

this is a review about the molecular, functional, and clinical aspects of Grb7 in erythroblastic leukemia viral oncogene homolog family-mediated cancer family-mediated cancer development and malignancy with the aim to reveal alternative and effective therapeutic strategies.[review]
It was identified that silencing of miR193a3p through hypermethylation can promote HER2 positive breast cancer progress by targeting GRB7, ERK1/2 and FOXM1 signaling.
MiR-193a-3p not only modulated GRB7 but also ERBB4.
Our results indicated that Grb7 over-expression may facilitate invasion and inhibit apoptosis in cervical cancer
data shows that GRB7 expression in invasive breast cancer correlates with markers of a more aggressive phenotype, including HER2 overexpression, a greater degree of HER2 amplification, ER negativity, and p53 positivity
The crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with the Grb7-SH2 domain.
Grb7 protein Ras-associating domain oligomerization has been reported.
Study provided a direct link between the signal adapter protein Grb7, anti-apoptotic protein Hax1 isoform 1, and Caspase3-mediated apoptosis pathways, and suggests that besides modulating cell migration and signal transduction, Grb7 may also participate in Hax1-related apoptosis pathways mediated by Caspase3.
Suggest close relationship between Grb7 gene amplification and GRB7 protein overexpression in human ovarian cancer. Immunohistochemistry might have limited diagnostic value in these tumors compared to fluorescence in situ hybridization.
Grb7 was found to be significantly related to the biological classification of breast cancer
apo Grb7 SH2 domain crystallized in the trigonal space group P63, whereas the G7-B1-Grb7 SH2 domain complex crystallized in the monoclinic space group P21
The data reveal that Grb7 plays an important role in breast cancer progression, beyond the context of HER2+ve cell types
Grb7 protein interacts with Filamin-a, an actin-crosslinking component of the cell cytoskeleton.
Data suggest that calmodulin controls Grb7-mediated cell migration.
Data propose the phosphorylation state of Grb7-SH2 domain tyrosine residues could control Grb7 dimerization, and dimerization may be an important regulatory step in Grb7 binding to RTKs such as erbB2.
GRB7 is a context-dependent oncogene, which modulates the ERBB2 signaling pathway through enhanced phosphorylation of ERBB2 and Akt.
propose that CaM inhibits the translocation of Grb7 to the nucleus after binding to its CaM-BD and therefore occluding its overlapping NLS
A series of Grb7 SH2 domain-binding nonphosphorylated peptides in the yeast two-hybrid system, were identified.
GRB7 protein over-expression is an independent adverse prognostic factor in human breast cancer
Full-length Grb7 and Hax-1 interact in mammalian cells and Grb7 is tyrosine phosphorylated.

GRB7 profil antigène

Antigen Summary

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with GRB7

growth factor receptor bound protein 7 (GRB7) anticorps
growth factor receptor bound protein 7 (Grb7) anticorps

GRB7 anticorps
mKIAA4028 anticorps

Protein level used designations for GRB7

growth factor receptor-bound protein 7 , growth factor receptor-bound protein 7-like , GRB7 adapter protein , Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) , epidermal growth factor receptor GRB-7 , growth factor receptor binding protein GRB7 , B47

GENE ID	SPECIES
454637	Pan troglodytes
100392059	Callithrix jacchus
100448630	Pongo abelii
100479529	Ailuropoda melanoleuca
100603732	Nomascus leucogenys
14786	Mus musculus
84427	Rattus norvegicus
100355891	Oryctolagus cuniculus
2886	Homo sapiens
100725019	Cavia porcellus
100513230	Sus scrofa
508847	Bos taurus
491021	Canis lupus familiaris
426597	Gallus gallus
101104589	Ovis aries

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Show all anti-Growth Factor Receptor-Bound Protein 7 (GRB7) Anticorps with Pubmed References

Mouse (Murine) Growth Factor Receptor-Bound Protein 7 (GRB7) interaction partners

Human Growth Factor Receptor-Bound Protein 7 (GRB7) interaction partners

Antigen Summary

Alternative names and synonyms associated with GRB7

Protein level used designations for GRB7