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Nck1 (Montrer NCK1 Anticorps) and Nck2 Interact with WTIP (Montrer WTIP Anticorps). Nck1 (Montrer NCK1 Anticorps)/2 integrates nephrin (Montrer NPHS1 Anticorps) with the Hippo kinase cascade through association with the adaptor protein WTIP (Montrer WTIP Anticorps).
Data suggest that PINCH1 (Montrer LIMS1 Anticorps) and Nck2 critically participate in the regulation of cellular radiosensitivity and EGFR (Montrer EGFR Anticorps) function and downstream signaling in a cellular model of human squamous cell carcinoma.
Tir-Intimin interaction recruits the Nck adaptor to a Tir tyrosine phosphorylated residue where it activates neural Wiskott-Aldrich syndrome protein (N-WASP).
Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.
NCK2 is involved in the susceptibility to opiates addiction.
The hNck2 SH3 domain (Montrer ITSN1 Anticorps) also exhibited pH dependent monomer-dimer transition.
Data show that both HK2 (Montrer HK2 Anticorps) and NCK2 are expressed in the retinal ganglion cell layer.
Nck2 effectively influences human melanoma phenotype progression.
p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.
Nck2 is an adaptor protein composed of 3N-SH3 domains followed by a unique Cterminal SH2 domain. It interacts with PINCH (Montrer LIMS1 Anticorps) in integrin signal transduction, cell migratio and survival. Review.
Authors propose that Nck2 should be further investigated as a regulator of the reliance of white adipose tissue on hyperplasia versus hypertrophy during adipose tissue expansion, and hence, as a potential novel molecular target in obesity.
Findings reveal that Nck2 is a novel regulator of adiposity and suggest that Nck2 is important in limiting WAT expansion and dysfunction in mice and humans.
Inactivation of NCK2 (and NCK1 (Montrer NCK1 Anticorps)) inhibits endothelial cell polarity.
These results reveal that Nck (Montrer NCK1 Anticorps) regulates preosteoblastic/osteoblastic migration and bone mass.
we show that the non-catalytic region of tyrosine kinase (Montrer NCK1 Anticorps) adaptor (NCK (Montrer NCK1 Anticorps)) proteins 1 and 2 are distributed in the developing spinal cord
Mouse embryos lacking endothelial Nck1 (Montrer NCK1 Anticorps)/2 expression develop extensive angiogenic defects that result in lethality at about embryonic day 10.
Data show that only Nck2 is required for the Slit1 (Montrer SLIT1 Anticorps)-induced changes in cortical neuron morphology in vitro.
These results revealed an essential role for HSF4-mediated SKAP2 expression in the regulation of actin reorganization during lens differentiation.
The Cas (Montrer CTNND1 Anticorps) utilizes Nck2 to activate Cdc42 (Montrer CDC42 Anticorps) and induce cell polarization in response to wound healing.
Nck1 (Montrer NCK1 Anticorps) and Nck2 have roles in cell movement and cytoskeletal organization
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
NCK adaptor protein 2
, cytoplasmic protein NCK2-like
, SH2/SH3 adaptor protein NCK-beta
, cytoplasmic protein NCK2
, growth factor receptor-bound protein 4
, noncatalytic region of tyrosine kinase, beta
, non-catalytic region of tyrosine kinase adaptor protein 2