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anti-Human NPY5R Anticorps:
anti-Mouse (Murine) NPY5R Anticorps:
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Human Polyclonal NPY5R Primary Antibody pour IHC (p), IHC - ABIN250423
Badman, Flier: The gut and energy balance: visceral allies in the obesity wars. dans Science (New York, N.Y.) 2005
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Human Polyclonal NPY5R Primary Antibody pour ELISA, IHC - ABIN185409
Sheriff, Ali, Yahya, Haider, Balasubramaniam, Amlal: Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line. dans Molecular cancer research : MCR 2010
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Y1R and Y5R might be the dominant receptors that mediate the effect of NPY-induced fat accumulation in both subcutaneous and visceral adipose tissues. Y1R and Y5R in visceral adipose tissue might be targets of drug development in prevention or treatment of obesity.
NPY5R is an inducible pro-survival factor that is responsible for chemoresistance in neuroblastoma cells.
Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans.
these data highlight a novel mechanism by which NPY may promote breast cancer progression, and further implicate a pathological role of the NPY Y5R.
Together, our results suggest that Y5R plays an important role in cancer cell growth and migration and could be a novel therapeutic target for breast cancer.
NPY1R and NPY5R have roles in nutrient-specific food intake in Europeans
The authenticity of this transcript was confirmed by isolating part of its 5'UTR and analysing its tissue distribution,, we have shown that the two AUG triplets contained in the 5' untranslated region of Y5(L) mRNA did not affect receptor expression
Functional studies of new ligands for this receptor.
Neuropeptide-Y induced endothelial cell migration was mimicked by agonists and fully blocked by antagonists for any specific NPY receptor (NPY5R).
single nucleotide polymorphisms in the NPY5R gene may have a role in dyslipidemia (elevated triglyceride concentrations and reduced high-density lipoprotein levels) in Mexican Americans
Sequence variations in neuropeptide Y receptor genes (NPY5R and NPY2R) are associated with alcohol dependence, cocaine dependence, and comorbid alcohol and cocaine dependence.
Results suggest that rabbit and human Y1, Y2 and Y5 receptor subtypes are well conserved, whereas Y4 receptors are less well conserved.
Study suggests that PYY3-36 mediated signalling via Y5 receptors may counteract the anorectic effects that it mediates via the Y2 receptor, consequently lowering bodyweight in the absence of Y5 signalling.
NPY and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage
Y5-immunoreactivity was distributed widely in mouse brain, and the Y5 protein localization was mostly observed in the somata of the Y5 neurons. By purifying the polyclonal antibody with fixed knockout mouse tissue, the precise Y5 localization became obvious in mouse brain, especially in areas other than the hypothalamic area.
Npy1r(Y5R-/-) mice show increased anxiety-related behavior but no changes in hypothalamus-pituitary-adrenocortical axis activity or in body weight growth, independently of gender and mouse strain used as foster mothers. Also, Npy1r(Y5R-/-) mice of both genders display increased spatial reference memory in the Morris water maze test.
Study shows pronounced adaptive changes in the mouse hippocampus both with regard to NPY synthesis and NPY receptor synthesis and binding, which may contribute to regulating neuronal seizure susceptibility after kainate
Y5 KO mice display increased grooming and rearing in the open field, lower ratio entries in open arms in the elevated plus maze and increased immobility time on the second day of the forced swim test
data indicate that Y5 antagonism may attenuate cocaine-induced behavioural effects.
These studies demonstrate the pivotal, combined role of both Y1 and Y5 receptors in the mediation of food intake.
These results do not support a potential role for single transgene overexpression of Y5 receptors for modulating anxiety-/depression-like behaviours or seizures in adult mice.
The Y5 receptor subtype, previously believed to mediate food intake, plays a critical role in modulation of hippocampal excitatory transmission at the hilar-to-CA3 synapse in the mouse
biological redundancies between Y1 and Y5 receptor signaling in the NPY-mediated control of food intake.
A limited distribution of Y5R expression is found in the hypothalamus; this receptor may be involved primarily in feeding and body weight control via neuropeptide Y's action on proopiomelanocortin-expressing neurons.
Taken together, these data suggest that, in mice, both Y2 and Y5 receptors regulate hippocampal seizures in vitro, while activation of Y5 receptors in extra-hippocampal regions reduces generalized seizures in vivo.
Results indicate that the NPY Y5 receptor Y5R is involved in the regulation and development of diet-induced obesity and suggest utility for Y5R antagonists in the treatment of obesity.
Npy5r antagonist-treated mice showed an up-regulation of uncoupling protein mRNA in brown adipose tissue (BAT) and white adipose tissue (WAT), suggesting that both BAT and WAT contribute to energy expenditure.
these data provide a detailed and comparative mapping of Y(1) and Y(5) receptor promoter activity within cells of the mouse brain
Show that spironolactone Y5 receptor antagonist has potent antiobesity effects in obese mice.
Feeding behavior and gene expression of appetite-related neuropeptides in mice lacking for neuropeptide Y Y5 receptor subclass.
These findings confirm an interaction between neuropeptide Y(1) and Y(5) receptors in the regulation of energy homeostasis.
Lower mRNA levels of neuropeptide Y receptor 1 (NPY1R) and NPY5R but not NPY or NPY2R in the central nucleus of the amygdala predicted elevated anxious temperament.
The objectives of this study were to identify single nucleotide polymorphisms in the bovine NPY5R gene.
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity).
, Y5 receptor
, neuropeptide Y receptor type 5
, Neuropeptide Y5 receptor
, G-protein coupled receptor
, neuropeptide Y receptor Y5
, NPY receptor 5
, neuropeptide Y receptor type 5-like
, NPY Y5
, neuropeptide Y5 receptor