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Human Monoclonal HPSE2 Primary Antibody pour ICC, FACS - ABIN438798
Bonner, Kerr-Conte, Gmyr, Queniat, Moerman, Thévenet, Beaucamps, Delalleau, Popescu, Malaisse, Sener, Deprez, Abderrahmani, Staels, Pattou: Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. dans Nature medicine 2015
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study of tissue expression profiles, polymorphisms of HPSE (Montrer HPSE Anticorps) and HPSE2 genes and changes of their mRNA levels in porcine alveolar macrophages (PAMs) induced by PRRSV; upon stimulation in healthy piglets with PRRSV, HPSE (Montrer HPSE Anticorps) mRNA was obviously upregulated, while HPSE2 mRNA did not induce a prominent change in PAMs
The results of this study the Heparanase 2 appeared overexpressed at different stages of Alzheimer disease.
our results suggest that heparanase 2 functions as a tumor suppressor in bladder cancer
we provide evidence that Hpa2 overexpression in head and neck cancer cells markedly reduces tumor growth
The most common HPA (Montrer HPSE Anticorps) genotypes among Saudis were HPA-1 (Montrer HPSE Anticorps) a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA (Montrer HPSE Anticorps)-4 a + b- (99%), HPA-5 (Montrer ITGA2 Anticorps) a + b- (76.5%), HPA (Montrer HPSE Anticorps)-6 a + b- (100%) and HPA (Montrer HPSE Anticorps)-15 a + b + (50%). The prevalent allele among the HPA (Montrer HPSE Anticorps) systems was (a), except in the HPA (Montrer HPSE Anticorps)-15 system where the (b) allele was found in 52% of the subjects.
HPSE2 mutations were found in one Urofacial syndrome family but not detected in patients with non-neurogenic neurogenic bladder and severe lower urinary tract dysfunction
Heparanase 2 is more intensely expressed in the glandular tissue of cancer than in nonneoplastic endometrium; the HPSE2 expression in the stromal tissue is higher in the nonneoplastic controls compared with cancer mainly in the secretory endometrium.
High expression of heparanase-2 is associated significantly with gastric tumor growth and differentiation
Data indicate that the overexpression of HPSE1 (Montrer HPSE Anticorps) and HPSE2 in the intervertebral degenerated discs suggests a role for these factors in mediating extracellular matrix remodeling in degenerative discs during disease development.
HPSE2 c.631T>C (p.Y211H) is a novel benign SNP and c.1628A>T (p.N543I) is the disease-causing mutation in urofacial syndrome.
Studies indicate that cathepsin L (Montrer CTSL1 Anticorps) as the heparanase (Montrer HPSE Anticorps) activating protease.
Deletion of Hpse2 cause the urofacial syndrome-like phenotype in mice.
This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants.
, heparanase 3
, heparanase-like protein
, inactive heparanase-2