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anti-Human Endothelin 1 Anticorps:
anti-Mouse (Murine) Endothelin 1 Anticorps:
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Human Monoclonal Endothelin 1 Primary Antibody pour IP, ELISA - ABIN560688
Ghoul, Serova, Astorgues-Xerri, Bieche, Bousquet, Varna, Vidaud, Phillips, Weill, Benhadji, Lokiec, Cvitkovic, Faivre, Raymond: Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. dans Cancer research 2009
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Dog (Canine) Monoclonal Endothelin 1 Primary Antibody pour ICC, FACS - ABIN152685
Talati, West, Blackwell, Loyd, Meyrick: BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. dans American journal of physiology. Lung cellular and molecular physiology 2010
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Human Monoclonal Endothelin 1 Primary Antibody pour IHC (fro), IRMA - ABIN2473438
Papalambros, Sigala, Georgopoulos, Menekakos, Giatromanolaki, Bastounis, Sivridis: Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: correlation with symptoms and aortic diameter. dans International journal of molecular medicine 2003
Study shows that cerebrovascular muscle cells can express endothelin-1 (ET-1). The production of ET-1 in cerebrovascular muscle cells stimulated by oxyhemoglobin occurs partially through the NF-[kappa]B signal pathway.
Plasma ET-1 levels of rabbits increased significantly in fluorinated groups compared with those in the control group.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
In a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased.
Data suggest elevated levels of endothelin-1, as exhibited in cardiovascular diseases, facilitate development of ventricular arrhythmia by steepening action potential duration restitution and by increasing beat-to-beat variability of repolarization.
High levels of ET-1 are closely associated with BBB (Montrer ALMS1 Anticorps) disruption. ET-1 may play an important role in the pathogenesis of secondary brain injury after ICH (Montrer ACE Anticorps).
After subarachnoid hemorrhage, the contractile response to ET-1 was enhanced, and the ET(A (Montrer EDNRA Anticorps)) receptor expression was upregulated in the basilar artery.
After acute pulmonary thromboembolism, thrombolytic and anti-inflammatory treatment could decrease acute lung injury induced by ET-1 and NF-kappaB (Montrer NFKB1 Anticorps) activation. [endothelin-1; NFKB]
The increase in myocardial distensibility induced by endothelin-1 is absent in heart failure and is dependent on nitric oxide and prostaglandin release.
Endothelin-1 enhances nuclear Ca2 (Montrer CA2 Anticorps)+ transients in atrial myocytes through Ins (Montrer INS Anticorps)(1,4,5)P3-dependent Ca2 (Montrer CA2 Anticorps)+ release from perinuclear Ca2 (Montrer CA2 Anticorps)+ stores
In conclusion, endothelial vWF (Montrer VWF Anticorps) knockdown prevented angiotensin II-induced ET-1 upregulation through attenuation of NOX-mediated O2- production.
sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (Montrer MAPK14 Anticorps) kinase-mediated production of superoxide from NADPH oxidase (Montrer NOX1 Anticorps) following ETA receptor activation
ET1 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest.
ET-1 contributes to formation of oedema during experimental sepsis by a novel mechanism involving increased HBP (Montrer HEBP1 Anticorps) release from neutrophils.
Endothelin-1 expression is upregulated following therapeutic hypothermia after cardiac arrest.
ET-1 produces contraction of the urinary bladder neck muscles via muscular ET(A (Montrer EDNRA Anticorps)) receptors coupled to extracellular Ca(2 (Montrer CA2 Anticorps)+) entry via VOC (L-type) and non-VOC channels.
Endothelin-1 elevation is not only a conserved phenomenon in a pig traumatic brain injury (TBI) model, but it is a likely target for understanding the observed enhanced vascular response to TBI.
interleukin-6 (Montrer IL6 Anticorps), endothelin ET-1, and apoptotic Bak (Montrer BAK1 Anticorps) and Bcl-XL (Montrer BCL2L1 Anticorps) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
ET-1 elicits a different pattern of Src (Montrer SRC Anticorps) family kinase (SFK) activation and might trigger a different pattern of SFK activation from that caused by ATP and UTP.
Compared with the untreated group, the levels of serum ET-1 after acute myocardial infarction and reperfusion were significantly decreased in the Xuefu Zhuyu-treated group.
EDN1 rs5370 polymorphism was associated with large artery stroke development.
Endothelin-1 is a regulator of Mena expression in the serous ovarian cancer.Endothelin-1 role in the invadopodian function.
Studied effects of dexamethasone on gene expression regulation of sirtuin 1 (SIRT1 (Montrer SIRT1 Anticorps)), interleukin 6 (IL6 (Montrer IL6 Anticorps)), and endothelin 1 (EDN1) in gingival derived aging stem cells. Dexamethasone downregulated expression of SIRT1 (Montrer SIRT1 Anticorps) and IL6 (Montrer IL6 Anticorps) but upregulated EDN1 in stem cells.
Baseline big ET-1>0.56pmol/L was independently associated with higher all-cause mortality and HFH among CRT (Montrer SLC6A8 Anticorps) recipients.
this study provides the first evidence that a 2-SNP haplotype of the ET-1 gene is associated with increased risk of hormone refractory prostate cancer
During exercise, we noted a rapid and significant reduction in venous ET-1 levels in obese subjects but no significant change in lean subjects.
Serum levels of miR (Montrer MLXIP Anticorps)-31 and endothelin-1are elevated in psoriasis vulgaris and are suggested to play significant roles in the pathophysiology of psoriasis.
Plasma big ET-1 level is a valuable independent predictor of ST in patients with coronary stents, especially in the acute coronary syndrome population.
Although our study revealed higher serum ET-1 and lower serum alpha-Klotho (Montrer KL Anticorps) levels in systemic sclerosis patients compared to healthy controls, there were not any significant correlations between their serum levels with severity of organ involvement.
plasma EDN1 levels were significantly increased in Korean patients with fibromyalgia syndrome (FMS (Montrer CSF1R Anticorps)) compared with those in healthy controls. EDN1 SNP was revealed to be associated with susceptibility to FMS (Montrer CSF1R Anticorps).
Endothelin-1 expression is increased in a model of kidney injury, along with fibroblast expansion.
strial capillary basement membrane thickening results in hypoxic stress further elevating extracellular matrix and ET-1 gene expression, exacerbating strial pathology
TWEAK (Montrer TNFSF12 Anticorps) may stimulate endothelial ET-1 synthesis, through the up-regulation of ECE-1 (Montrer ECE1 Anticorps).
c-Src tyrosine kinase (Montrer CSK Anticorps) mediates high glucose-induced endothelin-1 expression
SIX1 (Montrer SIX1 Anticorps) regulates dorsal arch development not only by inducing dorsal Jag1 (Montrer JAG1 Anticorps) expression but also by inhibiting endothelin 1 (Edn1) expression in the pharyngeal endoderm of the dorsal arch, thus preventing dorsal EDNRA (Montrer EDNRA Anticorps) signaling.
NOX4 (Montrer NOX4 Anticorps)-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 production.
in normal tissues the tandem of serine carboxypeptidases, Scpep1 (Montrer SCPEP1 Anticorps) and CathA likely constitutes an important part of the physiological mechanism responsible for the balanced elimination of heightened levels of ET-1 that otherwise would accumulate in tissues and consequently contribute to development of the hyper-proliferative corneal dystrophy and abnormal skin thickening
Newborn endothelial cells express high levels of ET-1 peptides, rapidly release ET-1 in response to endothelial stimulation, and initiate ET-1-mediated endothelium-dependent constriction
cellular and molecular mechanisms of ET-1 action in periodontitis
Taken together, these data indicate that during high-salt feeding, the autocrine actions of ET-1 via upregulation of the ETB (Montrer EDNRB Anticorps) receptor are critical for IMCD NO production, facilitating inhibition of ion reabsorption.
Phylogenetic analysis of conserved grhl (Montrer GHRL Anticorps)-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 (Montrer GRHL3 Anticorps) target gene, and this was confirmed by chromatin precipitation assays in embryos.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Data suggest that edn1/ednraa (Montrer EDNRA Anticorps) (endothelin-1/endothelin-1 receptor type A (Montrer EDNRA Anticorps)) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase (Montrer DNAH8 Anticorps) in zebrafish embryonic skin.
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.
activation of Endothelin-1 signaling in craniofacial patterning
Edn1 from the pharyngeal ectoderm signals through Ednra (Montrer EDNRA Anticorps) proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.
EDN-1 may be involved in the protection of sperm from phagocytosis by polymorphonuclear neutrophils in the bovine oviduct, supporting sperm survival until fertilization
Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2 (Montrer EDN2 Anticorps), EDN3 (Montrer EDN3 Anticorps)) and EDN (Montrer RNASE2 Anticorps)-converting enzymes (ECE1 (Montrer ECE1 Anticorps), ECE2 (Montrer ECE2 Anticorps)) are expressed in epithelial cells; EDN (Montrer RNASE2 Anticorps) receptors (EDNRA (Montrer EDNRA Anticorps), EDNRB (Montrer EDNRB Anticorps)) are present in smooth-muscle. Expression of EDN1, EDN2 (Montrer EDN2 Anticorps), and ECE2 (Montrer ECE2 Anticorps) is highest on day of ovulation. EDN (Montrer RNASE2 Anticorps)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (Montrer NOX1 Anticorps)-PKCalpha (Montrer PKCa Anticorps)-p(38)MAPK (Montrer MAPK1 Anticorps) and NFkappaB-MT1MMP (Montrer MMP14 Anticorps) signaling pathways along with a marked decrease in TIMP-2 (Montrer TIMP2 Anticorps) expression in the cells
We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 (Montrer PLA2G4A Anticorps) activity in the cell membrane.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS (Montrer NOS Anticorps) in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells.
Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels
prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis
LOX-1 (Montrer OLR1 Anticorps) and CD40 (Montrer CD40 Anticorps) synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.
Elevated local expression of ET-1 and Ednra/Ednrb (Montrer EDNRB Anticorps) during the peri (Montrer PLIN1 Anticorps)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Short-term hyperinsulinaemia leads to increased vascular resistance in the equine digit and increased expression of ET-1 in the laminar tissue.
This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species.
A new role for et-1 signaling during early neural crest specification is reported.
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
, gene for endothelin
, endothelin 1
, preproendothelin 1
, endothelin 1 L homeolog