SGI-1027
Aperçu rapide pour SGI-1027 (ABIN7233289)
Application
Chemical Name
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Fonction
- DNA methyltransferase inhibitor
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Attributs du produit
- Potent and selective inhibitor of DNA methyl transferase inhibiting DNMT1, DNMT3A and DNMT3B with comparable potency (IC50=12.5, 8.0 and 7.5 956M respectively). Treatment of various cancer cell lines with SGI-1027 results in selective degradation of DNMT1 (MG-132 sensitive) with minimal effect on DNMT3A and 3B at 2.5-5 μM. Prolonged treatment of RKO cells resulted in reexpression of silenced tumor suppressor genes. Synergizes with doxorubicin at growth inhibition in neuroblastoma cell lines. Disrupts the MKK3-MYC complex in cells and inhibits MYC transcriptional activity in colon and breast cancer cells.
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Pureté
- >98 %
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Formula
- C27H23N7O
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Solubility
- Soluble in DMSO (35 mg/ml)
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
Anacardic AcidInh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
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Restrictions
- For Research Use only
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Format
- Powder
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Stock
- -20 °C
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Sujet
- Epigenetics,Chromatin,DNA Methyltransferase,Prions,Cancer,Bcl,Myc
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Poids moléculaire
- 461.5
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Numéro CAS
- 1020149-73-8
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