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Tubastatin A HCl

Name: Tubastatin A HCl
Brand: antibodies-online
SKU: ABIN7233303
Price: 113.08 EUR
Availability: InStock

Inh Cell-permeable 1310693-92-5 N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride

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N° du produit ABIN7233303

Aperçu rapide pour Tubastatin A HCl (ABIN7233303)

Application

Inhibition (Inh)

Chemical Name

N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride

Perméabilité

Cell-permeable

Fonction

HDAC6 inhibitor

Attributs du produit

Potent and selective histone deacetylase 6 (HDAC6) inhibitor, IC50=15 nM (>1000-fold selective against other HDACs and 60-fold for HDAC8). Inhibits TNFα (IC50=272 nM) and IL-6 (IC50=712 nM) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models. Improves survival in animal models of sepsis. Improves cognition in Alzheimers disease transgenic mice. Cell permeable.

Pureté

>98 %

Formula

C20H22N3O2 • HCl

Solubility

Soluble in DMSO (up to 50 mg/ml).
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Radicicol
Inh 12772-57-5

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Phenylbutyrate Na
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Restrictions

For Research Use only
Format

Powder

Stock

-20 °C
Sujet

Epigenetics,Protein deacetylase,Neuroscience,Neurodegeneration,Inflammation,Posttranslational modification,Chromatin

Poids moléculaire

371.86

Numéro CAS

1310693-92-5