Pour une meilleure utilisation, nous vous conseillons d’activer Javascript dans votre navigateur.

UNC1999

Inh 1431612-23-5 N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide

1 image

N° du produit ABIN7233305

Aperçu rapide pour UNC1999 (ABIN7233305)

Application

Inhibition (Inh)

Chemical Name

N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide

Fonction

Methyltransferase inhibitor

Attributs du produit

UNC1999 is an orally active, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50's = 45 nM and 2 nM respectively). Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib in suppressing the proliferation of colon cancer cells. It suppresses global H3K27 trimethylation/demethylation and inhibits the growth of mixed lineage leukemia (MLL)-rearranged leukemia cells.

Pureté

>98 %

Formula

C33H43N7O2

Solubility

Soluble in DMSO (up to 10 mg/ml).
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

Anacardic Acid
Inh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Resveratrol
Act 501-36-0 3,4',5-Trihydroxy-trans-stilbene

SAHA (Vorinostat)
Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid

Phenylbutyrate Na
Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

Restrictions

For Research Use only
Format

Powder

Stock

-20 °C
Sujet

Epigenetics,Proliferation,Protein methyltransferase,Cancer,Posttranslational modification,Chromatin

Poids moléculaire

569.74

Numéro CAS

1431612-23-5