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Swinholide A

CC

N° du produit ABIN924961

Aperçu rapide pour Swinholide A (ABIN924961)

Application

Cell Culture (CC)

Fonction

Swinholide A is a natural dimeric dilactone macrolide toxin that causes actin depolymerization in cells.

Pureté

> 98 % (HPLC)
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

Anacardic Acid
Inh 16611-84-0 2-Hydroxy-6-pentadecylbenzoic acid

EX-527
Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Resveratrol
Act 501-36-0 3,4',5-Trihydroxy-trans-stilbene

SAHA (Vorinostat)
Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid

Phenylbutyrate Na
Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

Indications d'application

Can be used in cell biology to distinguish between the effects induced by increasing intracellular concentrations of G-actin from those induced by a reduction in F-actin.

Commentaires

Formula: C78H132O20

Restrictions

For Research Use only
Format

Oil

Stock

-20 °C
Sujet

Swinholide A is a 44-carbon dimeric dilactone ring macrolide isolated from the marine sponge Theonella swinhoei. In vitro, it sequesters actin dimers with a binding stochiometry of 1:1, and it rapidly severs F-actin with high cooperativity. Swinholice A is potently cytotoxic by disruption of the actin cytoskeleton. It does not block progression of cells through the cell cycle, but does prevent cytokinesis. Cytotoxcity: Cell Type IC50 (µg/ml) KB Oral, epidermoid cell carcinoma 0.04 HT-1080 Fibrosarcoma 0.017 PC-3 Lung, adenocarcinoma 6.0 PC-9 Lung, adenocarcinoma 0.13 PC-10 Lung, squamous cell carcinoma 0.11 PC-13 Lung, large cell carcinoma 0.10 Daudi Burkitt lymphoma 0.036.

Poids moléculaire

1388.9 Da

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