IL12 Kit ELISA

N° du produit ABIN2690561

Détail du produit IL12 Kit ELISA

Antigène: IL12 (Interleukin 12 (IL12))

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Gamme de detection: 7.8 - 500 pg/mL

Seuil minimal de détection: 7.8 pg/mL

Application: ELISA

Fonction: The human IL-12 (p70) ELISA Kit is for the in vitro quantitative determination of human IL-12 (p70) in serum, plasma, and cell culture supernatant.

Marque: BD OptEIA™

Type d'échantillon: Serum, Plasma, Cell Culture Supernatant

Analytical Method: Quantitative

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

BD OptEIA™ Human IL-12 (p70) ELISA Kit

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Stockage commentaire: 1. Store unopened kit at 2 - 8°C. Do not use kit after expiration date.
2. Before use, bring all reagents to room temperature (18 - 25°C). Immediately after use, return to proper storage conditions.
3. Lyophilized standards are stable until kit expiration date. After reconstitution, use freshly reconstituted standard within 12 hours (stored at 2 - 8°C).

Références pour IL12 Kit ELISA (ABIN2690561)

Ling, Gately, Gubler, Stern, Lin, Hollfelder, Su, Pan, Hakimi: "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 116-27, (1995) (PubMed).

Schoenhaut, Chua, Wolitzky, Quinn, Dwyer, McComas, Familletti, Gately, Gubler: "Cloning and expression of murine IL-12." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3433-40, (1992) (PubMed).

Détail du antigène

Antigène: IL12 (Interleukin 12 (IL12))

Autre désignation: IL-12 (IL12 Produits)

Synonymes: CLMF Kit ELISA, CLMF2 Kit ELISA, IL-12B Kit ELISA, NKSF Kit ELISA, NKSF2 Kit ELISA, p40 Kit ELISA, Il-12b Kit ELISA, Il12p40 Kit ELISA, Il-12p40 Kit ELISA, Il12 Kit ELISA, IL-12p40 Kit ELISA, IL-12 Kit ELISA, LOC100217488 Kit ELISA, IL-12p35 Kit ELISA, Il-12a Kit ELISA, Ll12a Kit ELISA, p35 Kit ELISA, IL12p40 Kit ELISA, IL12B Kit ELISA, IL-12 p35 Kit ELISA, interleukin 12B Kit ELISA, interleukin 12A Kit ELISA, interleukin 12b Kit ELISA, interleukin 12a Kit ELISA, Interleukin 12 level Kit ELISA, IL12B Kit ELISA, IL12A Kit ELISA, Il12b Kit ELISA, Il12a Kit ELISA, IL12 Kit ELISA, il12a Kit ELISA

Sujet: Human Interleukin-12 (p70) (hIL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a potent regulator of cell-mediated immune responses. Biologically active IL-12 is secreted by activated B lymphocytes and macrophages as a 70 kD heterodimeric glycoprotein composed of disulfide-bonded 35 kD (p35) and 40 kD (p40) subunits. The BD OptEIA™ kit specifically measures only this biologically active p70.
IL-12 stimulates the growth of activated CD4+ and CD8+ T cells and NK cells. IL-12 also promotes the development of proinflammatory-Th1-like CD4+ cells and cytotoxic CD8+ T cells. Other effects include increasing the lytic activity of NK cells and antibody-dependent cell-mediated cytotoxic cells, synergizing with IL-2 in the generation of lymphokine-activated killer (LAK) cells, and inducing NK and T cells to secrete large amounts of the proinflammatory cytokine, IFN-γ.

Pathways: Signalistation JAK/STAT, Signalisation TLR, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome