COL18A1 Kit ELISA
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- Antigène Voir toutes COL18A1 Kits ELISA
- COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
- Épitope
- AA 1591-1774
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Reactivité
- Rat
- Méthode de détection
- Colorimetric
- Type de méthode
- Sandwich ELISA
- Application
- ELISA
- Fonction
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Rat Endostatin
- Marque
- PicoKine™
- Analytical Method
- Quantitative
- Specificité
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Expression system for standard: NSO
Immunogen sequence: H1591-K1774 - Réactivité croisée (Details)
- There is no detectable cross-reactivity with other relevant proteins.
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- Discover our best selling COL18A1 Kit ELISA
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- Discover our top product COL18A1 Kit ELISA
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- Plaque
- Pre-coated
- Restrictions
- For Research Use only
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- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- Date de péremption
- 12 months
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- Antigène Voir toutes COL18A1 Kits ELISA
- COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))
- Autre désignation
- Endostatin (COL18A1 Produits)
- Synonymes
- KNO Kit ELISA, KNO1 Kit ELISA, KS Kit ELISA, cb371 Kit ELISA, cb529 Kit ELISA, fc96d06 Kit ELISA, sb:cb529 Kit ELISA, wu:fb47h10 Kit ELISA, wu:fb77g12 Kit ELISA, wu:fc50f04 Kit ELISA, wu:fc96d06 Kit ELISA, wu:fk02h12 Kit ELISA, kno Kit ELISA, kno1 Kit ELISA, collagen type XVIII alpha 1 chain Kit ELISA, collagen type XVIII alpha 1 chain a Kit ELISA, collagen, type XVIII, alpha 1 Kit ELISA, collagen type XVIII alpha 1 Kit ELISA, COL18A1 Kit ELISA, col18a1a Kit ELISA, Col18a1 Kit ELISA, col18a1 Kit ELISA
- Classe de substances
- Chemical
- Sujet
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Background: Endostatin is a naturally-occurring 20- kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. And It is produced by proteolytic cleavage of collagen XVIII, a member of the multiplexin family that is characterized by interruptions in the triple helix creating multiple domains, by proteases such as cathepsins. Using a genomic clone as a probe for fluorescence in situ hybridization, Endostatin was mapped the COL18A1 gene to 21q22.3. By immunoprecipitation analysis using membrane fractions of human mammary epithelial cells, It showed that endostatin specifically bound to cell surface nucleolin with high affinity. Blockage of nucleolin with neutralizing antibody or knockdown of nucleolin by RNA interference countered the antiendothelial activity of endostatin and abrogated its antiangiogenic and antitumor activity in vivo.
Synonyms: Collagen type XVIII, alpha (I) chain ,Col18a1 ,col18a1 ,
Full Gene Name: collagen, type XVIII, alpha 1
- UniProt
- Q9WUW5
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