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LATS1 Produits

(LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))

Catégories

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

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Catégories LATS1 en vedette

LATS1 Anticorps

High quality antibodies with extensive validation data.

LATS1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application ELISA, IHC, IP, IF
Validations
  • (5)
N° du produit ABIN7169059
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (1)
  • (2)
N° du produit ABIN391033
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (3)
N° du produit ABIN522568
Quantité 100 μg
Fiche technique Fiche technique

LATS1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6968208
Quantité 96 tests
Fiche technique Fiche technique

LATS1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Insect cells (Sf21)
Validations
  • (2)
N° du produit ABIN5570089
Quantité 5 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7123723
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1309191
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits LATS1

Moon, Lee, Lee, Lee, Park, Park, Chang, Park, Choi: "STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle." dans: Cells, Vol. 8, Issue 12, (2020) (PubMed).

Wigerius, Quinn, Diab, Clattenburg, Kolar, Qi, Krueger, Fawcett: "The polarity protein Angiomotin p130 controls dendritic spine maturation." dans: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).

Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." dans: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).

Grijalva, Huizenga, Mueller, Rodriguez, Brazzo, Camargo, Sadri-Vakili, Vakili: "Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration." dans: American journal of physiology. Gastrointestinal and liver physiology, Vol. 307, Issue 2, pp. G196-204, (2014) (PubMed).

Chan, Lim, Guo, Tan, Leung, Hong: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." dans: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).

Huang, Nagatomo, Suzuki, Mizuno, Kumagai, Berezov, Zhang, Karlan, Greene, Wang: "YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14." dans: Oncogene, Vol. 32, Issue 17, pp. 2220-9, (2013) (PubMed).

Salah, Melino, Aqeilan: "Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity." dans: Cancer research, Vol. 71, Issue 5, pp. 2010-20, (2011) (PubMed).

Mao, Mulvaney, Zakaria, Yu, Morgan, Allen, Basson, Francis-West, Irvine: "Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development." dans: Development (Cambridge, England), Vol. 138, Issue 5, pp. 947-57, (2011) (PubMed).

Oh, Lee, Kim, Kim, Oh, Hwang, Kong, Kwon, Lim: "Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse." dans: Molecular and cellular biology, Vol. 29, Issue 23, pp. 6309-20, (2009) (PubMed).

Eiring, Neviani, Santhanam, Oaks, Chang, Notari, Willis, Gambacorti-Passerini, Volinia, Marcucci, Caligiuri, Leone, Perrotti: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." dans: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).

Synonymes et noms alternatifs relatifs à LATS1

large tumor suppressor kinase 1 (LATS1), large tumor suppressor (Lats1), large tumor suppressor kinase 1 (lats1), large tumor suppressor kinase 1 (Lats1), large tumor suppressor kinase 1 S homeolog (lats1.S), AW208599, Lats, lats1, RGD1564085, si:dkey-181i3.5, WARTS, warts, wts, wu:fc19a11, zgc:123219

Protein level used designations for LATS1

  • LATS (large tumor suppressor, Drosophila) homolog 1
  • LATS, large tumor suppressor, homolog 1
  • WARTS protein kinase
  • h-warts
  • large tumor suppressor homolog 1
  • serine/threonine-protein kinase LATS1
  • large tumor supressor, homolog 1
  • large tumor suppressor 1
  • large tumor suppressor
  • LATS homolog 1
  • LATS, large tumor suppressor, homolog 1 (Drosophila)
  • serine/threonine-protein kinase LATS1-like
  • large tumor suppressor kinase 1 S homeolog
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