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Human Polyclonal WEE2 Primary Antibody pour ICC, IF - ABIN4366089
Dai, Zheng, Dai, Guo, Lu, Gong, Li, Zhou, Lu, Lin: New biallelic mutations in WEE2: expanding the spectrum of mutations that cause fertilization failure or poor fertilization. dans Fertility and sterility 2019
A high prevalence of WEE2 mutations was found in Chinese women experiencing fertilization failure or poor fertilization.
Novel variants found in WEE2, which is autosomal-recessive inherited, may be related to recurrent pronucleus formation failure and female infertility.
WEE2-AS1 over-expressed in HCC and was positively correlated to hepatitis B virus (HBV) infection, hepatic vascular invasion, poor tumor differentiation and poor patient prognosis. WEE2-AS1 also accelerated the proliferation, migration, invasion and cell cycle progression of HCC cells. A preliminary HBx-WEE2-AS1- FERMT3 pathway which may serve as a therapeutic target for HBV-associated HCC.
homozygous mutations in WEE2 that are responsible for fertilization failure in humans, were identified.
WEE1B acts as a direct downstream substrate of protein kinase A (PKA) and that Ser 15 of WEE1B is a potential PKA phosphorylation target in the G2/M transition of mouse embryos.
findings demonstrate that exit from metaphase requires not only a proteolytic degradation of cyclin B but also the inhibitory phosphorylation of Cdc2 by Wee1B
Wee1B is a key maturation-promoting-factor inhibitory kinase in mouse oocytes, functions downstream of PKA, and is required for maintaining meiotic arrest.
results suggest pWEE1B is activated after phosphorylation of the Ser77 residue, which is different from phosphorylation site that activates mWEE1B; that pWEE1B is localized in the nucleus; and that the nuclear localization is essential for its function
insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure of small oocytes in pigs
These results suggest that the inhibitory phosphorylation of CDC2, which is catalyzed by pigWee1B, but not pigMyt1, is involved in the meiotic arrest of porcine oocytes.
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Wee1-like protein kinase 1
, wee1-like protein kinase 2-B
, wee1-like protein kinase 1B
, wee1-like protein kinase 2
, wee1B kinase
, Wee1-like protein kinase 1B
, Wee1-like protein kinase 2
, Wee1B kinase