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anti-Mouse (Murine) Caveolin-1 Anticorps:
anti-Rat (Rattus) Caveolin-1 Anticorps:
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Human Monoclonal Caveolin-1 Primary Antibody pour FACS, ICC - ABIN152046
Souto, Vallega, Wharton, Vinten, Tranum-Jensen, Pilch: Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling. dans The Journal of biological chemistry 2003
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Human Polyclonal Caveolin-1 Primary Antibody pour WB - ABIN2801935
Glenney: The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles. dans FEBS letters 1992
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Human Polyclonal Caveolin-1 Primary Antibody pour IHC - ABIN965753
Maggi, Biedi, Segat, Barbero, Panetta, Cordera: IGF-I induces caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts. dans Biochemical and biophysical research communications 2002
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Rat (Rattus) Monoclonal Caveolin-1 Primary Antibody pour WB - ABIN2192105
Salani, Passalacqua, Maffioli, Briatore, Hamoudane, Contini, Cordera, Maggi: IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. dans PLoS ONE 2010
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Human Polyclonal Caveolin-1 Primary Antibody pour ICC, IHC (fro) - ABIN3044427
Wang, Zhao, Wu, He, Qu, Zhao, Zhao, Li, Wang: Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line. dans Asian Pacific journal of cancer prevention : APJCP 2013
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Human Polyclonal Caveolin-1 Primary Antibody pour ICC, IHC (fro) - ABIN3043803
Shi, Li, Jia, Ji, Song, Cheng, Wu, Song, Zhang, Zhu, Yang: MicroRNA-199a-5p affects porcine preadipocyte proliferation and differentiation. dans International journal of molecular sciences 2015
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Monoclonal Caveolin-1 Primary Antibody pour IF, IP - ABIN534131
Fork, Hitzel, Nichols, Tikkanen, Brandes: Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. dans Basic research in cardiology 2014
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Dog (Canine) Polyclonal Caveolin-1 Primary Antibody pour FACS, ICC - ABIN152668
Li, Liu, Pilcher, Anderson: Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasm or mitochondria. dans Journal of cell science 2001
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Human Caveolin-1 Primary Antibody pour IHC - ABIN965752
Zhang, Wolf-Yadlin, Ross, Pappin, Rush, Lauffenburger, White: Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. dans Molecular & cellular proteomics : MCP 2005
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Human Polyclonal Caveolin-1 Primary Antibody pour ICC, IP - ABIN1742344
Ferru-Clément, Fresquet, Norez, Métayé, Becq, Kitzis, Thoreau: Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells. dans PLoS ONE 2015
These results point to intestinal epithelial cell CAV1 as a potential therapeutic target to lower circulating free fatty acids and LDL cholesterol.
Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.
The development of transgenic zebrafish lines expressing CLTA fused to dsRed and CAV1 fused to GFP is reported.
maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin
These results support important and previously unanticipated roles for the Caveolin-1 isoforms in vertebrate organogenesis.
interactions of cav1 at lipid-exposed domains regulate the partition of the receptor into membrane raft microdomains
We developed a protocol to label B16F10 cells with AuNPs-PEG-TAT that permits subsequent tracking of cells in mice. CAV1 overexpression was found to increase retention and transendothelial migration of B16F10 cells in the lung.
Cav-1 deletion is able to suppress High Fat Diet-induced oxidative stress and dyslipidemia in ApoE-/- mice.
Transplantation of a denuded aorta into carotid artery leads to plaque formation. Caveolin-1 knockout leads to increased plaque formation. Additional knockout of eNOS in Cav1-/- aortae reduces plaque formation.
the CAV1-/- mice were characterized by a low-grade systemic proinflammatory status, with a moderate increase in the IL-6, TNF-alpha, and IL-12p70 levels CAV1-/- circulating lymphocytes were more prone to cytokine production upon nonspecific stimulation than the wild-type lymphocytes
data suggest that lung cancer cells escape oncogene-induced premature senescence through down-regulation of caveolin-1 expression to progress from premalignant lesions to cancer.
This study defines ZNRF1 as a regulator of TLR4-induced inflammatory responses and reveals another mechanism for the regulation of TLR4 signalling through CAV1.
Renal Cav1 promotes water and salt reabsorption via modulation of NCC function and regulation of vascular eNOS.
Sirt1 preserves Cav1-dependent endothelial function by mitigating miR-204-mediated vascular endoplasmic reticulum stress.
Cav1 is an important inhibitor of TGF-β1/Smad signaling in hepatic stellate cell activation and collagen production.
the present study indicated that Cav-1-/- accelerated liver injury in a mouse model of liver fibrosis through enhancing oxidative stress, inflammatory response and fibrosis progression
MURC binds to Cav1 and inhibits the association of Cav1 with the active form of Galpha13, resulting in the facilitated association of the active form of Galpha13 with p115RhoGEF. These results reveal that MURC has a function in the development of pulmonary hypertension through modulating Rho/ROCK signaling.
The part of PKC regulation of CaV1.2 in the heart involves changes in channel's cellular fate. The mechanism of this PKC regulation appears to involve the C-terminus of alpha1C, possibly corroborating the previously proposed role of NT-CT interactions within alpha1C.
Findings suggest that CAV1 might be involved in apoptosis and proliferation regulation in pancreatic beta cells.
Caveolin1 is required for Th1 cell infiltration, but not tight junction remodeling at the Blood-Brain Barrier in autoimmune neuroinflammation
Results suggest distinct functional roles for type 1 ryanodine receptor (RYR1) and Ca2+ channels-the 1,4-dihydropyridine receptor (Cav1.1) in skeletal primary and secondary myogenesis.
genetic deletion of Cav-1 exacerbated and cavtratin administration inhibited choroidal and retinal neovascularization
findings suggest that HMGB1 induces the transcytosis of albumin via RAGE-dependent Src phosphorylation and Cav-1 phosphorylation. These studies revealed a new mechanism of HMGB1-induced endothelial hyperpermeability.
caveolin-1 (Cav-1) participates in intraocular pressure maintenance via modulation of aqueous humor drainage from the eye.
DJ-1 has a role in glutamate uptake into astrocytes by regulating flotillin-1 and caveolin-1 expression
These results suggest that the phosphorylated CAV1 functions to activate autophagy through binding to the BECN1/VPS34 complex under oxidative stress and to protect against ischemic damage.
using proteomics profiling, we identified a new protein, caveolin-1 that is significantly and consistently augmented in CLL cells after these lymphocytes interact with stromal cell lines.
Study shows that ITGB1-dependent upregulation of caveolin-1 (CAV1) switches TGFbeta signalling from tumour-suppressive to oncogenic in prostate cancer. work suggests TGFbeta signalling and beta1 integrins as potential therapeutic targets in prostate cancer over-expressing CAV1, and contributes to better understand the paradoxical dual role of TGFbeta in tumour biology.
results showed that CAV-1 could promote anchorage-independent growth and anoikis resistance in detached SGC-7901 cells, which was associated with the activation of Src-dependent epidermal growth factor receptor-integrin beta signaling as well as the phosphorylation of PI3K/Akt and MEK/ERK signaling pathways
Cav-1 expression is up-regulated in endothelial cells of atherosclerotic lesions.
sinonasal inverted papillomas lesions presented increased Caveolin-1 immunopositivity compared to nasal polyposis. Also, smokers presented significantly increased immunopositivity.
we indicate that weak stromal CAV1 expression in CRLM is an adverse prognostic factor in patients who undergo liver resection for liver-only colorectal metastases.
Study provides evidence that KIF13B and NPHP4 are both required for establishment of a specialized caveolin-1 membrane microdomain at the ciliary transition zone, which is essential for Shh-induced accumulation of SMO in the primary cilium as well as for activation of GLI-mediated target gene expression.
High CAV1 expression is associated with gastric cancer cell migration.
Study shows that progression-related loss of stromal caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistance.
Results found decreasing trend of cav-1 (transcripts I and II) in tumoral tissues especially in stages I and II and seem to be associated with the incidence and promotion of breast cancer, especially in the initial stages of breast cancer.
minor alleles for SNPs rs3779512, rs7804372 and rs1049337 might be associated with a higher risk of hypertriglyceridemia.
stromal expression of CAV1 in primary tumors was not associated with clinical outcome whereas the stromal expression of especially CAV2 in the metastatic lymph nodes could be associated with lung cancer pathogenesis.
CAV-1 is important for NAFLD-HCC survival in fatty acid-rich environments and is a potential therapeutic target.
At the onset of mitotic cell rounding, caveolin-1 is targeted to the retracting cortical region at the proximal end of retraction fibres, where ganglioside GM1-enriched membrane domains with clusters of caveola-like structures are formed in an integrin and RhoA-dependent manner.
down-regulation of Cav-1 may aggravate DNA damage of Chang liver cells through reducing the interaction of Cav-1 and Mdm2, which results in the promotion of p53 degradation.
High CAV1 expression is associated with Small Cell Lung Cancer.
NEDD8 seems to inhibit the Src-mediated phosphorylation of caveolin-1 by modifying the structure of caveolin-1 protein, which blocks the migration of cancer cells. Although the neddylation process is currently regarded as an emerging target for cancer therapy, our results suggest the possibility that the inhibition of neddylation could facilitate cancer invasion or metastasis at least in some types of cancers.
High CAV1 expression is associated with Aggressive Behaviour of Breast Cancer.
Cav1 and PY14Cav1 were positively correlated with ESCC lymphatic metastasis and cancer stages. Rho/ROCK pathway activation promoted ESCC metastasis by regulating Cav1.
we revisited the question of the relationship between Cav1 and Stat3-ptyr705 in non-transformed mouse fibroblasts and in human lung carcinoma cells, by examining their effect at different cell densities.Our results demonstrate that Cav1 downregulates cadherin-11, by a mechanism which requires the Cav1 scaffolding domain. This cadherin-11 downregulation, leads to a reduction in cRac1 and Stat3 activity levels.
Caveolin-1 is a modulator of fibroblast activation and a potential biomarker for gastric cancer
transcription factor Sp1 interacts with nucleotides -123/-114, indicating that Sp1 could play a key role in the transcriptional regulation of pig CAV-1
Two alternative transcript variants encode two isoforms, caveolin-1-alpha and -beta; Cav1 may be implicated in pathogenesis of Glasser's disease of swine.
The plasma membrane Na/K-ATPase-caveolin-1 interaction may represent an important sensing mechanism by which the cells regulate the sterol regulatory element-binding protein pathway.
The present study indicates that caveolin-containing rafts/caveolins such as caveolin-1 could play a modulating role during oligodendroglial differentiation and regeneration via NGF/TrkA signaling.
Cav-1 might be a candidate gene for carcass traits, and might provide valuable information for understanding the mechanism of caveolae signaling in fat deposition by using the animal model of pig
ATRA is able to ameliorate highfatinduced AS in rabbits, which is mediated through the activation of eNOS and downregulating CAV1 expression.
Caveolin-1 expression ameliorates nephrotic damage in a rabbit model of cholesterol-induced hypercholesterolemia.
8-Bromo-cAMP stimulated alpha-methyl-D-glucopyranoside uptake via Epac and PKA-dependent SGLTs expression and trafficking through cav-1 and F-actin in proximal tubule cells.
Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling
Data show that resveratrol (Res) reversed caveolin-1 (Cav-1)/endothelial nitric oxide synthase (eNOS) expressions in high glucose cultured bovine aortic endothelial cells (BAECs).
these data provide the first detailed analysis of Cav-1 binding to one of its most significant client proteins, eNOS.
Study identifies a critical role of caveolin-1 in the regulation of eNOS uncoupling via a biopterin-dependent mechanism.
Data indicate that caveolin-1 expression is required for insulin uptake by aortic endothelial cells.
caveolin-1 is not required for the targeting of signaling molecules to caveolae/lipid rafts
integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk association at integrin sites, where it plays a role in downstream, shear-stimulated myelin light chain diphosphorylation.
importance of CAV1 amino acids 89-95 and particularly F92 in mediating eNOS inhibition by AP-Cav and Cav-1
When endothelial cells were exposed to shear stress, caveolin-1 was transiently dephosphorylated.
alphaCAV1 likely contributes to control the increase in membrane signaling that occurs at the time of ovulation and luteinization.
caveolin-1 tyrosine 14 phosphorylation has a role in cell adhesion and migration
caveolin-1 Tyr(14) is necessary for binding to intermediate filaments, which in turn is required for anterior polarization of caveolin-1 in transmigrating cells
Phosphorylation of CAV1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase is reported.
XIAP plays a novel role in endothelial cells, interacting with caveolin-1 and acting as a regulator of vascular antiatherogenic function.
These data show that insulin acutely regulates eNOS and CAV-1 trafficking to plasma membrane of vascular endothelial cells where their interaction can regulate eNOS activity.
TGF-beta1 downregulates caveolin-1 of cultured endothelial cells, involving ALK-5 receptor subtype
The distribution of CAV-1 is highly dynamic during development and provides new insights into the sorting mechanisms that regulate CAV-1 localization.
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
, caveolin 1
, caveolin, caveolae protein 1
, caveolin, caveolae protein, 22 kDa
, caveolin caveolae protein 22 kDa
, vesicular integral-membrane protein VIP21
, cell growth-inhibiting protein 32
, testis derived transcript