Merlin Produits
(Neurofibromin 2 (NF2))
Catégories
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development\; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008].
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Catégories Merlin en vedette
Merlin Anticorps
High quality antibodies with extensive validation data.
Merlin Kits ELISA
Reliable ELISA kits for a wide range of species.
Merlin Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Merlin recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, IP
Validations
- (6)
N° du produit
ABIN6144548
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
N° du produit
ABIN7434395
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (3)
N° du produit
ABIN7441928
Quantité
100 μL
Fiche technique
Fiche technique
Merlin recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6968860
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6958099
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380639
Quantité
2 x 96 tests
Fiche technique
Fiche technique
Merlin recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1312430
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7504952
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7395359
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Merlin
: "An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice." dans: Cell stem cell, Vol. 21, Issue 1, pp. 91-106.e6, (2018) (PubMed).: "Influence of Membrane Receptor Lateral Diffusion on the Short-Term Depression of Acetylcholine-Induced Current in Helix Neurons." dans: Cellular and molecular neurobiology, (2017) (PubMed).
: "Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP." dans: Genes & development, Vol. 29, Issue 12, pp. 1285-97, (2015) (PubMed).
: "Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators." dans: Development (Cambridge, England), Vol. 140, Issue 16, pp. 3323-34, (2013) (PubMed).
: "Cellular expression profile for interstitial cells of cajal in bladder - a cell often misidentified as myocyte or myofibroblast." dans: PLoS ONE, Vol. 7, Issue 11, pp. e48897, (2012) (PubMed).
: "Expression of P2X7 receptor increases in vivo tumor growth." dans: Cancer research, Vol. 72, Issue 12, pp. 2957-69, (2012) (PubMed).
: "Combining Curcumin (Diferuloylmethane) and Heat Shock Protein Inhibition for Neurofibromatosis 2 Treatment: Analysis of Response and Resistance Pathways." dans: Molecular cancer therapeutics, (2011) (PubMed).
: "The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals." dans: Developmental cell, Vol. 19, Issue 1, pp. 27-38, (2010) (PubMed).
: "Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cells." dans: Journal of cell science, Vol. 122, Issue Pt 22, pp. 4141-9, (2010) (PubMed).
: "The phosphorylation status of merlin in sporadic vestibular Schwannomas." dans: Molecular and cellular biochemistry, Vol. 324, Issue 1-2, pp. 201-6, (2009) (PubMed).
Synonymes et noms alternatifs relatifs à Merlin
neurofibromin 2 (NF2), neurofibromin 2 (Nf2), neurofibromin 2a (merlin) (nf2a), neurofibromin 2b (merlin) (nf2b), neurofibromin 2 (merlin) S homeolog (nf2.S), ACN, BANF, merlin, NF2, nf2, NF2a, SCH, zgc:194620, zgc:194631Protein level used designations for Merlin
- merlin
- moesin-ezrin-radixin like
- moesin-ezrin-radixin-like protein
- moesin-ezrin-radizin-like protein
- neurofibromin 2 (bilateral acoustic neuroma)
- neurofibromin-2
- schwannomerlin
- schwannomin
- neurofibromin 2
- neurofibromatosis 2
- LOW QUALITY PROTEIN: merlin
- neurofibromin 2 (merlin) S homeolog
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