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MKL1 Produits

(Megakaryoblastic Leukemia (Translocation) 1 (MKL1))

Catégories

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. [provided by RefSeq, Jul 2008].

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Catégories MKL1 en vedette

MKL1 Anticorps

High quality antibodies with extensive validation data.

MKL1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (3)
N° du produit ABIN7264553
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IF, IP
Validations
  • (3)
N° du produit ABIN6143855
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Pig, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
N° du produit ABIN1387286
Quantité 100 μL
Fiche technique Fiche technique

MKL1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6968520
Quantité 96 tests
Fiche technique Fiche technique

MKL1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3093809
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3136609
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits MKL1

Whitson, Lee, Urman, Mirza, Yao, Brown, Li, Shankar, Fry, Atwood, Lee, Hollmig, Aasi, Sarin, Scott, Epstein, Tang, Oro: "Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas." dans: Nature medicine, Vol. 24, Issue 3, pp. 271-281, (2018) (PubMed).

Gjorevski, Piotrowski, Varner, Nelson: "Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices." dans: Scientific reports, Vol. 5, pp. 11458, (2015) (PubMed).

Record, Malinova, Zenner, Plagnol, Nowak, Syed, Bouma, Curtis, Gilmour, Cale, Hackett, Charras, Moulding, Nejentsev, Thrasher, Burns: "Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1." dans: Blood, Vol. 126, Issue 13, pp. 1527-35, (2015) (PubMed).

Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." dans: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).

Schmidt, Duncan, Yadav, Regan, Verone, Lohse, Pop, Attwood, Wilding, Mohler, Sebo, Tindall, Heemers: "RhoA as a mediator of clinically relevant androgen action in prostate cancer cells." dans: Molecular endocrinology (Baltimore, Md.), Vol. 26, Issue 5, pp. 716-35, (2012) (PubMed).

Muehlich, Hampl, Khalid, Singer, Frank, Breuhahn, Gudermann, Prywes: "The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1." dans: Oncogene, Vol. 31, Issue 35, pp. 3913-23, (2012) (PubMed).

Synonymes et noms alternatifs relatifs à MKL1

megakaryoblastic leukemia (translocation) 1 (MKL1), megakaryoblastic leukemia 1 protein (mkl1), megakaryoblastic leukemia (translocation) 1 (Mkl1), megakaryoblastic leukemia (translocation) 1 S homeolog (mkl1.S), MKL (megakaryoblastic leukemia)/myocardin-like 1 (Mkl1), AI852829, AMKL, AW743281, AW821984, BSAC, Bsac, MAL, Mal, MKL1, MRTF-A, Mrtf-a, mrtf-a, Mrtf-A, mrtfa

Protein level used designations for MKL1

  • megakaryoblastic leukemia 1 protein
  • MKL/myocardin-like protein 1
  • RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein
  • basic, SAP and coiled-coil domain
  • megakaryocytic acute leukemia protein
  • myocardin-related transcription factor A
  • xMRTF-A
  • basic SAP and coiled-coil domains
  • basic SAP coiled-coil transcription activator
  • megakaryoblastic leukemia (translocation) 1 homolog
  • megakaryoblastic leukemia 1 protein homolog
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