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The presence of two different isoforms in the myocardium close to the insertion of pacing is suggestive of a differential state-specific expression of A2AR in cardiac tissue.
Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death.
Activation of adenosine A2A receptors in hypoxic conditions is associated with an enhanced vasorelaxation in porcine coronary arteries.
Adenosine evokes dilation of porcine pial arterioles via parallel activation of endothelial and smooth muscle AA receptors.
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model.
hypoxia-induced coronary artery dilatation is not mediated by increased adenosine produced within the artery wall but might be facilitated by increased adenosine sensitivity at the A(2A) receptor level
Activation of adenosine A(2A) receptors inhibited ROS production by LPS-stimulated equine neutrophils in a cAMP-dependent manner.
Adenosine A2A receptor immunoreactivity is localized at the highest levels of the striatum and external globus pallidus.
report a differential, activation state-specific expression of ADORA in microglia and uncover a role for A(3)R as dynamically regulated suppressors of A(2A)R-mediated inhibition of TLR-induced responses
Expressed primarily within the central nervous system. Zebrafish AdRs may serve as useful targets for testing novel therapeutic strategies for the treatment of Parkinson's disease.
Here, ligand-binding kinetics of the full-length human adenosine A2A receptor (A2AR) reconstituted in detergent micelles were measured using a fluorescently labeled ligand via fluorescence anisotropy.
alpha2A- and alpha2C-adrenoceptors are functional receptors for norepinephrine, dopamine, and other previously assumed selective D2-like receptor ligands.
Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations have been described.
monocyte-derived macrophages from ankylosing spondylitis patients expressed increased levels of A2AAR and reduced levels of A1 and A2BAR compared to healthy controls
expression A2AR mRNA in PBMCs was associated with asthma severity. Foxp3 mRNA, TGF-beta, and FEV1%pred positively correlated with A2AR mRNA in asthma.
This study reported associations between the c.1083T>C polymorphism in the adenosine A2A receptor gene (ADORA2A) and sleep variables
Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation has been reported.
These data indicate that low [Na(+)] is required to allow large agonist-induced structural changes in A2AR, and that patterns of sidechain dynamics substantially differ between agonist (NECA) and inverse agonist (ZM241385) bound receptors, with the inverse agonist suppressing fast picosecond-nanosecond timescale motions at the G protein binding site.
Low adenosine A2a receptor expression is associated with ulcerative colitis.
Results demonstrate that A2AR act on GR nuclear translocation and GR-dependent transcriptional regulation which suggest that A2AR is a major regulator of GR function and that this functional interconnection may be a trigger to age-related memory deficits.
the present study indicates that A2bR may play a potential oncogenic role in BUC progression and act as a potential biomarker to identify BUC patients with poor clinical outcomes.
Report prognostic impact of ADORA2A expression in non-small lung cancers.
genetic association studies in population in Germany: Data suggest that an SNP in ADORA2A (1976T/C, rs5751876) is associated with interoceptive (resting) and exteroceptive (executive function/task-based) processing in frontal lobe and insular cortex neural networks. Facilitated processing of interoceptive/exteroceptive information in salience network is suggested to promote development of anxiety and anxiety disorders.
A2A receptor stimulation promotes collagen type III synthesis via the activation of canonical and non-canonical beta-catenin, consistent with a role for A2A receptors in dermal fibrosis and scarring.
It is significantly associated with hippocampal volume and the minor allele of rs9608282 in ADORA2A is associated with larger hippocampal volumes and better memory.
Study corroborated results from a previous report that described interactions between ADORA2A and CYP1A2 polymorphisms and coffee consumption in Parkinson's disease.
However, the contribution of the A2AR to the control of impulsive reward seeking remains unknown. Using mice that were exposed to differential reward of low rate (DRL) schedules during Pavlovian-conditioning, second-order schedule discrimination, and the 5-choice serial reaction time task (5-CSRTT), we demonstrate that deficits of A2AR function promote impulsive responses.
Western blot analysis indicates that the A2A receptor is more abundant in the hippocampus of medial temporal lobe epilepsy patients compared to control individuals. Immunoreactivity against the A2A receptor predominates in astrocytes staining positively for the glial fibrillary acidic protein.
Results suggest that the combination of the ADORA2A rs2298383TT and MTHFR 1298AC-677CT genotypes might lead to a low risk of nodule formation in patients treated with methotrexate.
Hypoxic postconditioning protects against apoptosis induced by reoxygenation via activation of adenosine A2a receptors on dermal microvascular endothelial cells.
Study demonstrates that cognitive functions, including spatial memory and mood, are impaired due to acute hypobaric hypoxia (HH); and demonstrate that genetic inactivation of A2AR prevented spatial memory impairment in acute HH model of mice. The underlying mechanism might include microglia-mediated neuroinflammation via A2AR activation in the hippocampus.
Cigarette smoke impairs A2A adenosine receptor mediated wound repair through up-regulation of Duox-1 expression.
The present study evaluates the behavioral effects of pharmacological manipulation and genetic blockade of A2A R and D2 R within the frame of such a predominant striatal heteromeric population.
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.
importance for MC5r and A2Ar expression in EAU to promote the induction of protective regulatory immunity, and the expression of MC5r and A2Ar on human immune cells, suggests that it may be possible to utilize the melanocortin-adenosinergic pathways to induce protective immunity in uveitic patients
Body weight was significantly smaller in A2AR-KO mice at the age of 6 months
Results show overall cognitive impairments in A2A adenosine receptor knockout mice associated with a decrease in new-born hippocampal neuron proliferation and concomitant changes in synaptic protein expression, in both the prefrontal cortex and the hippocampus.
aged mice have a lower ability to cope with inflammation due to C. albicans over-colonization, associated with an inability to adaptively adjust adenosine A2A receptors density
A2AR activation enhances its interaction with endothelial glutamate transporters. Inhibition of A2AR rescued dysfunction of brain endothelial glutamate transporters.
The astrocytic Lrp4 plays an important role in ischemic brain injury response. Lrp4 deficiency in astrocytes seems to be protective in response to ischemic brain injury, likely because of the increased ATP release and adenosine-A2AR signaling.
the potential effects of the A2A adenosine receptor (A2AR) antagonist SCH 5826 (SCH) and agonist CGS 21680 (CGS) on behavior (self-grooming), hot plate test results, and expression levels of IL-17A(+), RORgammat(+), Foxp3(+), and IL-10(+) in CD4(+) T spleen cells in BTBR and C57BL/6 (B6) mice, were investigated.
Compared to adults, young WT mice failed to control S. pneumoniae infection after vaccination and this was associated with lower levels of CD73 on innate B cells. We hypothesized that pharmacological activation of A2a receptor may improve Pneumovax 23 immunization in young WT mice
Absence of A2AAR increases cochlear resistance to acoustic trauma.
Behavioral, anatomical and neurochemical studies to assess psychotic-like symptoms in adult male and female A2AR KO and wild-type littermates. Results bolster the adenosine hypothesis of schizophrenia by demonstrating behavioral and anatomical alterations associated with the specific deletion of adenosine A2AR. These findings resemble most of the relevant phenotype features of the human disorder.
Adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1alpha pathway.
it is concluded that the anxiolytic-like activities of rubimetide and typical agonist peptides of the FPR2 were mediated successively by the PGD2-DP1 receptor, adenosine-A2A receptor, and GABA-GABAA receptor systems downstream of the FPR2.
Study focused on the impact of A2A receptor deletion (A2A receptor knockout, A2AKO) on motivation for social exploration. Although A2AKO mice showed an anxious profile, they displayed higher levels of sociability and were less sensitive to social novelty. c-Fos immunoreactivity in A2AKO mice was higher in anterior cingulate and amygdala compared to wild type mice.
data showed that A2AARs control pancreatic dysfunction in HFD-induced obesity
Data indicate A2ARs exert minor effects in un-stressed myocardium and selectively suppress NFkappaB and JAK-STAT signalling and cardiac injury without influencing cardiac depression in endotoxemia.
The three receptor sets considered (mAChR, AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings.
Selective activation of A(1), A(2A), or A(3) adenosine receptors provides significant protection against lung ischemia-reperfusion injury.
Study reveals presence of adenosine A(2A) and A(2B) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.
This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.
adenosine A2a receptor
, adenosine receptor A2a
, adenosine receptor A2a.1
, adenosine receptor subtype A2a
, A2a, Rs
, Adenosine A2a-receptor
, adenosine receptor A2a-like