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The presence of two different isoforms in the myocardium close to the insertion of pacing is suggestive of a differential state-specific expression of A2AR in cardiac tissue.
Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death.
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model.
Activation of adenosine A(2A) receptors inhibited ROS (Montrer ROS1 Protéines) production by LPS (Montrer IRF6 Protéines)-stimulated equine neutrophils in a cAMP-dependent manner.
Adenosine A2A receptor immunoreactivity is localized at the highest levels of the striatum and external globus pallidus.
monocyte-derived macrophages from ankylosing spondylitis patients expressed increased levels of A2AAR and reduced levels of A1 and A2BAR (Montrer ADORA2B Protéines) compared to healthy controls
expression A2AR mRNA in PBMCs was associated with asthma severity. Foxp3 (Montrer FOXP3 Protéines) mRNA, TGF-beta (Montrer TGFB1 Protéines), and FEV1%pred positively correlated with A2AR mRNA in asthma.
This study reported associations between the c.1083T>C polymorphism in the adenosine A2A receptor gene (ADORA2A) and sleep variables
Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation has been reported.
These data indicate that low [Na(+)] is required to allow large agonist-induced structural changes in A2AR, and that patterns of sidechain dynamics substantially differ between agonist (NECA) and inverse agonist (ZM241385) bound receptors, with the inverse agonist suppressing fast picosecond-nanosecond timescale motions at the G protein binding site.
Low adenosine A2a receptor expression is associated with ulcerative colitis.
Results demonstrate that A2AR act on GR nuclear translocation and GR-dependent transcriptional regulation which suggest that A2AR is a major regulator of GR function and that this functional interconnection may be a trigger to age-related memory deficits.
the present study indicates that A2bR (Montrer ADORA2B Protéines) may play a potential oncogenic role in BUC progression and act as a potential biomarker to identify BUC patients with poor clinical outcomes.
Report prognostic impact of ADORA2A expression in non-small lung cancers.
genetic association studies in population in Germany: Data suggest that an SNP in ADORA2A (1976T/C, rs5751876) is associated with interoceptive (resting) and exteroceptive (executive function/task-based) processing in frontal lobe and insular cortex neural networks. Facilitated processing of interoceptive/exteroceptive information in salience network is suggested to promote development of anxiety and anxiety disorders.
Early synaptic deficits in the APP (Montrer APP Protéines)/PS1 (Montrer PSEN1 Protéines) mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.
importance for MC5r (Montrer MC5R Protéines) and A2Ar expression in EAU to promote the induction of protective regulatory immunity, and the expression of MC5r (Montrer MC5R Protéines) and A2Ar on human immune cells, suggests that it may be possible to utilize the melanocortin-adenosinergic pathways to induce protective immunity in uveitic patients
Body weight was significantly smaller in A2AR-KO mice at the age of 6 months
A2AR activation enhances its interaction with endothelial glutamate (Montrer GRIN1 Protéines) transporters. Inhibition of A2AR rescued dysfunction of brain endothelial glutamate (Montrer GRIN1 Protéines) transporters.
The astrocytic Lrp4 (Montrer CORIN Protéines) plays an important role in ischemic brain injury response. Lrp4 (Montrer CORIN Protéines) deficiency in astrocytes seems to be protective in response to ischemic brain injury, likely because of the increased ATP release and adenosine-A2AR signaling.
the potential effects of the A2A adenosine receptor (A2AR) antagonist SCH (Montrer NF2 Protéines) 5826 (SCH (Montrer NF2 Protéines)) and agonist CGS 21680 (CGS) on behavior (self-grooming), hot plate test results, and expression levels of IL-17A (Montrer IL17A Protéines)(+), RORgammat(+), Foxp3 (Montrer FOXP3 Protéines)(+), and IL-10 (Montrer IL10 Protéines)(+) in CD4 (Montrer CD4 Protéines)(+) T spleen cells in BTBR and C57BL/6 (B6) mice, were investigated.
Absence of A2AAR increases cochlear resistance to acoustic trauma.
Behavioral, anatomical and neurochemical studies to assess psychotic-like symptoms in adult male and female A2AR KO and wild-type littermates. Results bolster the adenosine hypothesis of schizophrenia by demonstrating behavioral and anatomical alterations associated with the specific deletion of adenosine A2AR. These findings resemble most of the relevant phenotype features of the human disorder.
Adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK (Montrer EPHB2 Protéines)/Akt (Montrer AKT1 Protéines)/HIF-1alpha (Montrer HIF1A Protéines) pathway.
it is concluded that the anxiolytic-like activities of rubimetide and typical agonist peptides of the FPR2 (Montrer FPR2 Protéines) were mediated successively by the PGD2 (Montrer PTGDS Protéines)-DP1 (Montrer REEP5 Protéines) receptor, adenosine-A2A receptor, and GABA-GABAA (Montrer GABRg1 Protéines) receptor systems downstream of the FPR2 (Montrer FPR2 Protéines).
Study reveals presence of adenosine A(2A) and A(2B (Montrer ADRA2B Protéines)) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.
This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.
adenosine A2a receptor
, adenosine receptor A2a
, adenosine receptor A2a.1
, adenosine receptor subtype A2a
, A2a, Rs
, Adenosine A2a-receptor
, adenosine receptor A2a-like