PANK2 Produits
(Pantothenate Kinase 2 (PANK2))
Catégories
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008].
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Catégories PANK2 en vedette
PANK2 Anticorps
High quality antibodies with extensive validation data.
PANK2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PANK2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Dog, Human, Monkey, Rat
Application
WB, IHC, IF, IHC (p), FACS
Validations
- (8)
N° du produit
ABIN1500026
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
N° du produit
ABIN7162603
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (3)
N° du produit
ABIN566414
Quantité
100 μg
Fiche technique
Fiche technique
PANK2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6206931
Quantité
96 tests
Fiche technique
Fiche technique
PANK2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN3013381
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3085454
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7421605
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PANK2
: "Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients." dans: Neurobiology of disease, (2015) (PubMed).: "Glycyrrhizin suppresses lung adenocarcinoma cell growth through inhibition of thromboxane synthase." dans: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 33, Issue 2, pp. 375-88, (2014) (PubMed).
: "DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis." dans: The Journal of cell biology, Vol. 206, Issue 2, pp. 183-97, (2014) (PubMed).
: "Regulation of murine hepatic hydroxysteroid sulfotransferase expression in hyposulfatemic mice and in a cell model of 3'-phosphoadenosine-5'-phosphosulfate deficiency." dans: Drug metabolism and disposition: the biological fate of chemicals, Vol. 41, Issue 8, pp. 1505-13, (2013) (PubMed).
: "Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model." dans: Human molecular genetics, Vol. 21, Issue 24, pp. 5294-305, (2012) (PubMed).
: "An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria." dans: Human molecular genetics, Vol. 12, Issue 3, pp. 321-7, (2003) (PubMed).
: "Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic." dans: Neurology, Vol. 61, Issue 10, pp. 1423-6, (2003) (PubMed).
: "HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration." dans: Neurology, Vol. 58, Issue 11, pp. 1673-4, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à PANK2
pantothenate kinase 2 (PANK2), pantothenate kinase 2 (Tsp_01576), pantothenate kinase 2, mitochondrial (LOC100539295), pantothenate kinase 2 (Pank2), ribonuclease A family member 11 (inactive) (RNASE11), 4933409I19Rik, AI642621, ATPANK2, C20orf48, F10M6.180, F10M6_180, HARP, HSS, NBIA1, PANK2, pantothenate kinase 2, PKANProtein level used designations for PANK2
- pantothenate kinase 2 (Hallervorden-Spatz syndrome)
- pantothenate kinase 2
- pantothenate kinase 2, mitochondrial-like
- Hallervorden-Spatz syndrome
- pantothenate kinase 2, mitochondrial
- pantothenic acid kinase 2
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