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PCBP2 Produits

(Poly(rC) Binding Protein 2 (PCBP2))

Catégories

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Catégories PCBP2 en vedette

PCBP2 Anticorps

High quality antibodies with extensive validation data.

PCBP2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PCBP2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (1)
  • (8)
N° du produit ABIN3023340
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IF, ICC, IHC (p), IP
Validations
  • (1)
  • (6)
N° du produit ABIN2856965
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IF, IHC (p), RNAi
Validations
  • (9)
  • (8)
N° du produit ABIN562121
Quantité 100 μg
Fiche technique Fiche technique

PCBP2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6208966
Quantité 96 tests
Fiche technique Fiche technique

PCBP2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1314129
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
N° du produit ABIN2728353
Quantité 20 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3085703
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits PCBP2

Gupta, Singh, Pandey, Seth, Mukhopadhyay: "Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation." dans: Biochimica et biophysica acta. General subjects, Vol. 1863, Issue 3, pp. 547-564, (2019) (PubMed).

Colognori, Sunwoo, Kriz, Wang, Lee: "Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X." dans: Molecular cell, Vol. 74, Issue 1, pp. 101-117.e10, (2019) (PubMed).

Wu, Lou, Ge, Xiong: "Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos." dans: Scientific reports, Vol. 7, Issue 1, pp. 4022, (2018) (PubMed).

Lin, Yang, Liu, Tan, Wu, Hu, Jiang, Bao, Yuan, Qiang, Peng, Han: "Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion." dans: Oncotarget, Vol. 7, Issue 15, pp. 19483-98, (2016) (PubMed).

Yanatori, Richardson, Imada, Kishi: "Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2." dans: The Journal of biological chemistry, Vol. 291, Issue 33, pp. 17303-18, (2016) (PubMed).

Školáková, Foldynová-Trantírková, Bednářová, Fiala, Vorlíčková, Trantírek: "Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA." dans: Nucleic acids research, Vol. 43, Issue 9, pp. 4733-45, (2015) (PubMed).

Li, Masaki, Shimakami, Lemon: "hnRNP L and NF90 interact with hepatitis C virus 5'-terminal untranslated RNA and promote efficient replication." dans: Journal of virology, Vol. 88, Issue 13, pp. 7199-209, (2014) (PubMed).

Flynn, Martin, Spitale, Do, Sagan, Zarnegar, Qu, Khavari, Quake, Sarnow, Chang: "Dissecting noncoding and pathogen RNA-protein interactomes." dans: RNA (New York, N.Y.), Vol. 21, Issue 1, pp. 135-43, (2014) (PubMed).

Han, Xin, Zhao, Bao, Lin, Yin, Zhao, Yuan, Qiang, Peng: "RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3." dans: The Journal of clinical investigation, Vol. 123, Issue 5, pp. 2103-18, (2013) (PubMed).

Fujimura, Sasaki, Anderson: "Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules." dans: Nucleic acids research, Vol. 40, Issue 16, pp. 8099-110, (2012) (PubMed).

Synonymes et noms alternatifs relatifs à PCBP2

poly(rC) binding protein 2 (PCBP2), poly(rC) binding protein 2 (Pcbp2), poly(rC) binding protein 2 (pcbp2), poly(rC) binding protein 2 L homeolog (pcbp2.L), alphaCP-2, AW412548, fb36h02, hnRNP-E2, HNRNPE2, HNRPE2, Hnrpx, PCBP2, PCBP3, wu:fb36h02, zgc:55964

Protein level used designations for PCBP2

  • alpha-CP2
  • heterogeneous nuclear ribonucleoprotein E2
  • heterogenous nuclear ribonucleoprotein E2
  • hnRNP E2
  • poly(rC)-binding protein 2
  • CBP
  • CTBP
  • heterogeneous nuclear ribonucleoprotein X
  • hnRNP X
  • putative heterogeneous nuclear ribonucleoprotein X
  • poly(rC) binding protein 2
  • poly(rC) binding protein 3
  • PolyrC-binding protein 2
  • poly(rc)-binding protein 2
  • heterogeneous nuclear ribonucleoprotein
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