PC Produits
(Pyruvate Carboxylase (PC))
Catégories
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
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Catégories PC en vedette
PC Anticorps
High quality antibodies with extensive validation data.
PC Kits ELISA
Reliable ELISA kits for a wide range of species.
PC Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PC recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
N° du produit
ABIN7441475
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (3)
N° du produit
ABIN238663
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IHC (p)
Validations
- (2)
N° du produit
ABIN2890557
Quantité
100 μL
Fiche technique
Fiche technique
PC recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969792
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6959001
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6959002
Quantité
96 tests
Fiche technique
Fiche technique
PC recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7399316
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7409011
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2730236
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PC
: "Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntington's disease." dans: Chemico-biological interactions, Vol. 315, pp. 108907, (2020) (PubMed).: "Generation of Human Pyruvate Carboxylase Knockout Cell Lines Using Retrovirus Expressing Short Hairpin RNA and CRISPR-Cas9 as Models to Study Its Metabolic Role in Cancer Research." dans: Methods in molecular biology (Clifton, N.J.), Vol. 1916, pp. 273-288, (2019) (PubMed).
: "Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1." dans: Cell metabolism, Vol. 28, Issue 2, pp. 268-281.e4, (2018) (PubMed).
: "Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis." dans: Nature cell biology, Vol. 17, Issue 10, pp. 1317-26, (2015) (PubMed).
: "Diet-induced obesity in the selenocysteine lyase knockout mouse." dans: Antioxidants & redox signaling, Vol. 23, Issue 10, pp. 761-74, (2015) (PubMed).
: "Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 beta cells." dans: Molecular and cellular endocrinology, Vol. 383, Issue 1-2, pp. 48-59, (2014) (PubMed).
: "Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice." dans: Nature medicine, Vol. 20, Issue 11, pp. 1263-9, (2014) (PubMed).
: "Enhanced Ca(2+)-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model." dans: Neurobiology of disease, Vol. 58, pp. 192-9, (2013) (PubMed).
: "Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism." dans: PLoS pathogens, Vol. 7, Issue 7, pp. e1002124, (2011) (PubMed).
: "Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme." dans: Science (New York, N.Y.), Vol. 317, Issue 5841, pp. 1076-9, (2007) (PubMed).
Synonymes et noms alternatifs relatifs à PC
Pyruvate carboxylase (PCB), pyruvate carboxylase b (pcxb), PYruvate Carboxylase (pyc-1), pyruvate carboxylase (PC), pyruvate carboxylase (pyc), pyruvate carboxylase Pyr1 (pyr1), pyruvate carboxylase (CNF00650), Pyruvate carboxylase (PYC1), pyruvate carboxylase (Ndas_1152), pyruvate carboxylase (Ilyop_2503), pyruvate carboxylase (Calni_0495), pyruvate carboxylase (Ftrac_1004), pyruvate carboxylase (Plabr_3574), pyruvate carboxylase (Sgly_2936), pyruvate carboxylase (Celly_0558), pyruvate carboxylase (Hipma_0131), pyruvate carboxylase (Halhy_1567), pyruvate carboxylase (Mesop_1269), pyruvate carboxylase (Pcx), pyruvate carboxylase (Pc), BA4157, BcDNA, BcDNA:GH06348, Dmel\\CG1516, PC, Pc, Pcb, PCB, PCX, Pcx, pyc, wu:fb82g08, wu:fj85g01Protein level used designations for PC
- CG1516-PA
- CG1516-PB
- CG1516-PD
- CG1516-PE
- CG1516-PG
- CG1516-PI
- CG1516-PJ
- CG1516-PK
- CG1516-PL
- CG1516-PM
- CG1516-PP
- GH06348
- pyruvate carboxykinase
- pyruvate carboxylase
- PYCb
- pyruvate carboxylase, mitochondrial
- PYruvate Carboxylase family member (pyc-1)
- Pyruvate carboxylase
- pyruvate decarboxylase
- pyruvic carboxylase
- PCB
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