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PDE4A Produits

(phosphodiesterase 4A, CAMP-Specific (PDE4A))

Catégories

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].

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Catégories PDE4A en vedette

PDE4A Anticorps

High quality antibodies with extensive validation data.

PDE4A Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PDE4A recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IF, FACS, IHC (p)
Validations
  • (7)
N° du produit ABIN1500089
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
N° du produit ABIN7243706
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (3)
N° du produit ABIN7269302
Quantité 100 μL
Fiche technique Fiche technique

PDE4A recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6231741
Quantité 96 tests
Fiche technique Fiche technique

PDE4A recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
N° du produit ABIN2728507
Quantité 20 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3132310
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3094538
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits PDE4A

Ale-Agha, Goy, Jakobs, Spyridopoulos, Gonnissen, Dyballa-Rukes, Aufenvenne, von Ameln, Zurek, Spannbrucker, Eckermann, Jakob, Gorressen, Abrams, Grandoch, Fischer, Köhrer, Deenen, Unfried, Altschmied et al.: "CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine. ..." dans: PLoS biology, Vol. 16, Issue 6, pp. e2004408, (2018) (PubMed).

Lee, Shin, Hong: "The Regulatory Role of Rolipram on Inflammatory Mediators and Cholinergic/Adrenergic Stimulation-Induced Signals in Isolated Primary Mouse Submandibular Gland Cells." dans: Mediators of inflammation, Vol. 2016, pp. 3745961, (2017) (PubMed).

Avila, Barker, Zhang, McClain, Barve, Gobejishvili: "Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis." dans: The Journal of pathology, Vol. 240, Issue 1, pp. 96-107, (2017) (PubMed).

Taniguchi, Iizumi, Watanabe, Masuda, Morita, Aono, Toriyama, Oishi, Goi, Sakai: "Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer." dans: Cell death & disease, Vol. 7, pp. e2211, (2016) (PubMed).

Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." dans: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." dans: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Kedia, Ückert, Oelke, Sonnenberg, Sohn, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human male urethra." dans: Urology, Vol. 85, Issue 4, pp. 964.e1-6, (2015) (PubMed).

Yougbaré, Boire, Roy, Lugnier, Rouseau: "NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production." dans: Canadian journal of physiology and pharmacology, Vol. 91, Issue 5, pp. 353-61, (2014) (PubMed).

Guo, Lin, Zhao, Zhang, Wei, Wang, Wang: "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." dans: Neuroscience, Vol. 263, pp. 1-14, (2014) (PubMed).

Zhai, Chang, Wei, Liu, Leblais, Fischmeister, Ji: "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." dans: Cellular signalling, Vol. 26, Issue 5, pp. 1001-10, (2014) (PubMed).

Synonymes et noms alternatifs relatifs à PDE4A

phosphodiesterase 4A S homeolog (pde4a.S), phosphodiesterase 4A, cAMP-specific (pde4a), phosphodiesterase 4A (PDE4A), phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) (PDE4A), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (LOC100009247), phosphodiesterase 4A (Pde4a), phosphodiesterase 4A (pde4a), phosphodiesterase 4A, cAMP specific (Pde4a), phosphodiesterase 4C (PDE4C), phosphodiesterase 4A, cAMP-specific (PDE4A), D9Ertd60e, dpde2, Dpde2, DPDE2, pde4, PDE4, PDE4A, Pde4a, pde46, PDE46, PHOSA

Protein level used designations for PDE4A

  • phosphodiesterase 4A, cAMP-specific
  • phosphodiesterase 4A-like
  • phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
  • cyclic AMP-specific phosphodiesterase FCPDE4A1A
  • cyclic AMP-specific phosphodiesterase OCPDE4A1A
  • phosphodiesterase 4A, cAMP specific
  • cyclic AMP-specific phosphodiesterase CPPDE4A1A
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4A
  • cAMP-specific phosphodiesterase PDE4A
  • cyclic AMP specific phosphodiesterase PDE4A5A
  • dunce
  • phosphodiesterase 4A, cAMP-specific (dunce
  • phosphodiesterase E2 dunce homolog, Drosophila
  • phosphodiesterase isozyme 4
  • DPDE2
  • cyclic AMP-specific phosphodiesterase SSPDE4A1A
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