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PDE4B Produits

(phosphodiesterase 4B, cAMP-Specific (PDE4B))
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Catégories PDE4B en vedette

PDE4B Anticorps

High quality antibodies with extensive validation data.

PDE4B Kits ELISA

Reliable ELISA kits for a wide range of species.

PDE4B Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PDE4B recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (6)
N° du produit ABIN7442141
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB, ELISA, IHC
Validations
  • (3)
N° du produit ABIN185574
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
N° du produit ABIN7146632
Quantité 100 μg
Fiche technique Fiche technique

PDE4B recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969261
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958532
Quantité 96 tests
Fiche technique Fiche technique

PDE4B recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3094409
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1314464
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
N° du produit ABIN2728514
Quantité 20 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PDE4B

Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." dans: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

Johanns, Lai, Hsu, Jacobs, Vertommen, Van Sande, Dumont, Woods, Carling, Hue, Viollet, Foretz, Rider: "AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B." dans: Nature communications, Vol. 7, pp. 10856, (2016) (PubMed).

Cedervall, Aulabaugh, Geoghegan, McLellan, Pandit: "Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 12, pp. E1414-22, (2015) (PubMed).

Nagy, Ross, Rodriguez, Balint, Szeles, Nagy, Kirken: "Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells." dans: PLoS ONE, Vol. 8, Issue 2, pp. e57326, (2013) (PubMed).

Vang, Housley, Dong, Basole, Ben-Sasson, Kream, Epstein, Clark, Brocke: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." dans: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).

Fatemi, King, Reutiman, Folsom, Laurence, Lee, Fan, Paciga, Conti, Menniti: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." dans: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).

Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling." dans: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1187-91, (2005) (PubMed).

Barette, Jariel-Encontre, Piechaczyk, Piette: "Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity." dans: Oncogene, Vol. 20, Issue 5, pp. 551-62, (2001) (PubMed).

Johnson, Walker: "Cyclins and cell cycle checkpoints." dans: Annual review of pharmacology and toxicology, Vol. 39, pp. 295-312, (1999) (PubMed).

Synonymes et noms alternatifs relatifs à PDE4B

phosphodiesterase 4B (pde4b), phosphodiesterase 4B (PDE4B), phosphodiesterase 4B, cAMP specific (Pde4b), phosphodiesterase 4B (Pde4b), phosphodiesterase 4B S homeolog (pde4b.S), dpde4, Dpde4, DPDE4, dunce, PDE4/IVb, Pde4B1, Pde4B2, Pde4B3, Pde4B4, pde4b5, PDE4B5, pdeivb, PDEIVB, R74983

Protein level used designations for PDE4B

  • phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog)
  • phosphodiesterase 4B, cAMP-specific
  • phosphodiesterase 4B
  • 3',5'-cyclic AMP phosphodiesterase
  • DPDE4
  • Phosphodiesterase 4B cAMP-specific (dunce
  • Phosphodiesterase 4B, cAMP-specific (dunce
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
  • PDE32
  • cAMP-specific phosphodiesterase-4 B isoform
  • dunce-like phosphodiesterase E4
  • phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
  • phosphodiesterase 4B, cAMP specific
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