PDE4B Produits
(phosphodiesterase 4B, cAMP-Specific (PDE4B))
Catégories
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
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Catégories PDE4B en vedette
PDE4B Anticorps
High quality antibodies with extensive validation data.
PDE4B Kits ELISA
Reliable ELISA kits for a wide range of species.
PDE4B Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PDE4B recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (6)
N° du produit
ABIN7442141
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (3)
N° du produit
ABIN185574
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7146632
Quantité
100 μg
Fiche technique
Fiche technique
PDE4B recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969261
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6958532
Quantité
96 tests
Fiche technique
Fiche technique
PDE4B recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1314464
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7414258
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3094409
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits PDE4B
: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." dans: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).: "AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B." dans: Nature communications, Vol. 7, pp. 10856, (2016) (PubMed).
: "Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 12, pp. E1414-22, (2015) (PubMed).
: "Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells." dans: PLoS ONE, Vol. 8, Issue 2, pp. e57326, (2013) (PubMed).
: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." dans: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).
: "PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia." dans: Schizophrenia research, Vol. 101, Issue 1-3, pp. 36-49, (2008) (PubMed).
: "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling." dans: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1187-91, (2005) (PubMed).
: "Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity." dans: Oncogene, Vol. 20, Issue 5, pp. 551-62, (2001) (PubMed).
: "Cyclins and cell cycle checkpoints." dans: Annual review of pharmacology and toxicology, Vol. 39, pp. 295-312, (1999) (PubMed).
Synonymes et noms alternatifs relatifs à PDE4B
phosphodiesterase 4B (pde4b), phosphodiesterase 4B (PDE4B), phosphodiesterase 4B, cAMP specific (Pde4b), phosphodiesterase 4B (Pde4b), phosphodiesterase 4B S homeolog (pde4b.S), dpde4, Dpde4, DPDE4, dunce, PDE4/IVb, Pde4B1, Pde4B2, Pde4B3, Pde4B4, pde4b5, PDE4B5, pdeivb, PDEIVB, R74983Protein level used designations for PDE4B
- phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog)
- phosphodiesterase 4B, cAMP-specific
- phosphodiesterase 4B
- 3',5'-cyclic AMP phosphodiesterase
- DPDE4
- Phosphodiesterase 4B cAMP-specific (dunce
- Phosphodiesterase 4B, cAMP-specific (dunce
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B
- PDE32
- cAMP-specific phosphodiesterase-4 B isoform
- dunce-like phosphodiesterase E4
- phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
- phosphodiesterase 4B, cAMP specific
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