This is a synthetic peptide designed for use in combination with anti-CDNF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
CDNF is a trophic factor for dopamine neurons. CDNF prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, CDNF restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.