This is a synthetic peptide designed for use in combination with anti- TDG Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
TDG
Reactivité: Humain, Boeuf (Vache), Souris, Rat
Hôte: Synthetic
BP
Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Stock
-20 °C
Stockage commentaire
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Antigène
TDG
(Thymine-DNA Glycosylase (TDG))
Synonymes
5-MCDG Peptide, wu:fb44b11 Peptide, zgc:110622 Peptide, MGC82456 Peptide, MGC89441 Peptide, E130317C12Rik Peptide, JZA-3 Peptide, Jza1 Peptide, hTDG Peptide, thymine DNA glycosylase Peptide, thymine DNA glycosylase, tandem duplicate 1 Peptide, putative g/t mismatch-specific thymine DNA glycosylase Peptide, G/T mismatch-specific thymine DNA glycosylase Peptide, thymine DNA glycosylase S homeolog Peptide, thymine-DNA glycosylase Peptide, TDG Peptide, tdg.1 Peptide, Smp_149220 Peptide, Tsp_05734 Peptide, tdg.S Peptide, tdg Peptide, Tdg Peptide
Sujet
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.