This is a synthetic peptide designed for use in combination with anti-PIGA Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Stock
-20 °C
Stockage commentaire
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Antigène
PIGA
(Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA))
Synonymes
GPI3 Peptide, MCAHS2 Peptide, PIG-A Peptide, AI194334 Peptide, Pig-a Peptide, im:6911675 Peptide, zgc:56589 Peptide, phosphatidylinositol glycan anchor biosynthesis class A Peptide, phosphatidylinositol glycan anchor biosynthesis, class A Peptide, PIGA Peptide, Piga Peptide, piga Peptide
Sujet
This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.