TATA Box Binding Protein (TBP) (Middle Region) Peptide
TBP
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits TBP
- TBP (TATA Box Binding Protein (TBP))
- Protein Region
- Middle Region
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- QQQQQQQQQQ QQQQQQQQQQ QAVAAAAVQQ STSQQATQGT SGQAPQLFHS
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti- TBP Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- TBP (TATA Box Binding Protein (TBP))
- Synonymes
- GTF2D Peptide, GTF2D1 Peptide, HDL4 Peptide, SCA17 Peptide, TFIID Peptide, Gtf2d Peptide, fd20h06 Peptide, si:zc101n13.2 Peptide, wu:fd20h06 Peptide, zgc:66213 Peptide, TBP1 Peptide, TBP Peptide, tbp Peptide, CG9874 Peptide, Dmel\\CG9874 Peptide, RBP Peptide, TBP38 Peptide, TFIIDtau Peptide, TfIID Peptide, dTBP Peptide, dTFIID Peptide, dTbp Peptide, dtbp Peptide, gtf2d Peptide, gtf2d1 Peptide, sca17 Peptide, tfiid Peptide, tfiidtau Peptide, xtbp Peptide, tbp-a Peptide, tbp-b Peptide, TATA-box binding protein Peptide, TATA box binding protein Peptide, TATA binding protein Peptide, TATA-box binding protein L homeolog Peptide, TATA-box-binding protein Peptide, TATA-box binding protein S homeolog Peptide, TBP Peptide, Tbp Peptide, tbp Peptide, tbp.L Peptide, tbp.S Peptide
- Sujet
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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HDL4, GTF2D, SCA17, TFIID, GTF2D1
Protein Size: 319 - ID gène
- 6908
- NCBI Accession
- NM_001172085, NP_001165556
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