General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2) (N-Term) Peptide
GTF2H2
Reactivité: Humain
Hôte: Synthetic
BP, WB
-
- Antigène Tous les produits GTF2H2
- GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))
- Protein Region
- N-Term
- Origine
- Humain
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-GTF2H2 antibody (Catalog #: P100893_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Antigène
- GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))
- Synonymes
- 44kDa Peptide, BTF2 p44 Peptide, BTF2-p44 Peptide, Btf2p44 Peptide, p44 Peptide, BTF2 Peptide, BTF2P44 Peptide, T-BTF2P44 Peptide, TFIIH Peptide, general transcription factor II H, polypeptide 2 Peptide, general transcription factor IIH subunit 2 Peptide, general transcription factor IIH, polypeptide 2, 44kDa Peptide, Gtf2h2 Peptide, GTF2H2 Peptide
- Sujet
-
GTF2H2 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. GTF2H2 is the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs, however, no sequence data is currently available for the centromeric copy of the gene.This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs, however, no sequence data is currently available for the centromeric copy of the gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-15 BM083743.1 1-15 16-1121 AF078847.1 1-1106 1122-1537 BG283896.1 128-543 1538-1951 AC044797.5 132110-132523 c
Alias Symbols: BTF2, BTF2P44, MGC102806, T-BTF2P44, TFIIH, p44
Protein Interaction Partner: CDK7,ERCC2,ERCC3,ERCC8,GTF2H1,GTF2H5,CCNH,CDK7,ERCC2,ERCC3,GTF2H1,GTF2H4,GTF2H5
Protein Size: 395 - Poids moléculaire
- 44 kDa
- ID gène
- 2966
- NCBI Accession
- NM_001515, NP_001506
- UniProt
- Q13888
-
Vous êtes ici:
