Hyaluronan Synthase 1 (HAS1) (N-Term) Peptide
HAS1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits HAS1
- HAS1 (Hyaluronan Synthase 1 (HAS1))
- Protein Region
- N-Term
- Origine
- Humain
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- EPAAAGAVGA GAYREVEAED PGRLAVEALV RTRRCVCVAQ RWGGKREVMY
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-HAS1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- HAS1 (Hyaluronan Synthase 1 (HAS1))
- Synonymes
- dg42 Peptide, Xhas1 Peptide, HAS Peptide, shas1 Peptide, hyaluronan synthase 1 Peptide, hyaluronan synthase 1 S homeolog Peptide, has1 Peptide, HAS1 Peptide, Has1 Peptide, has1.S Peptide
- Sujet
-
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis.
Alias Symbols: HAS
Protein Interaction Partner: EIF6,VHL
Protein Size: 578 - Poids moléculaire
- 64 kDa
- ID gène
- 3036
- NCBI Accession
- NM_001523, NP_001514
- UniProt
- Q92839
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