Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA) (N-Term) Peptide
HLA-DMA
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits HLA-DMA
- HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
- Protein Region
- N-Term
- Origine
- Humain
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- GLSEAYDEDQ LFFFDFSQNT RVPRLPEFAD WAQEQGDAPA ILFDKEFCEW
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-HLA-DMA Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
- Synonymes
- RT1.Ma Peptide, RT1.DMa Peptide, HLA-DMA Peptide, H-2Ma Peptide, H2-Ma Peptide, D6S222E Peptide, DMA Peptide, HLADM Peptide, RING6 Peptide, RT1 class II, locus DMa Peptide, SLA-DM alpha chain Peptide, major histocompatibility complex, class II, DM alpha Peptide, histocompatibility 2, class II, locus DMa Peptide, RT1-DMa Peptide, SLA-DMA Peptide, DLA-DMA Peptide, H2-DMa Peptide, HLA-DMA Peptide
- Sujet
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HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Alias Symbols: D6S222E, DMA, HLADM, RING6
Protein Interaction Partner: CD74,CD82,HLA-DMB,HLA-DOA,HLA-DRA,HLA-DRB1,HLA-DRB1
Protein Size: 261 - Poids moléculaire
- 29 kDa
- ID gène
- 3108
- NCBI Accession
- NM_006120, NP_006111
- UniProt
- Q31604
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