Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5B (KIR2DL5B) (C-Term) Peptide
KIR2DL5B
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits KIR2DL5B
- KIR2DL5B (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5B (KIR2DL5B))
- Protein Region
- C-Term
- Origine
- Humain
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- DQDPQEVTYA QLDHCVFTQT KITSPSQRPK APPTDTTMYM ELPNAKPRSL
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-KIR2DL5B Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- KIR2DL5B (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5B (KIR2DL5B))
- Synonymes
- KIR2DL5 Peptide, KIR2DL5.2 Peptide, KIR2DLX Peptide, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B Peptide, KIR2DL5B Peptide
- Sujet
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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
Alias Symbols: KIR2DL5, KIR2DL5.2, KIR2DLX
Protein Size: 375 - Poids moléculaire
- 38 kDa
- ID gène
- 553128
- NCBI Accession
- NM_001018081, NP_001018091
- UniProt
- Q8NHK4
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