Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) Peptide
TGFBR2
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits TGFBR2
- TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-TGFBR2 antibody (Catalog #: ARP44743_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))
- Synonymes
- AAT3 Peptide, FAA3 Peptide, LDS1B Peptide, LDS2B Peptide, MFS2 Peptide, RIIC Peptide, TAAD2 Peptide, TGFR-2 Peptide, TGFbeta-RII Peptide, 1110020H15Rik Peptide, AU042018 Peptide, DNIIR Peptide, RIIDN Peptide, TBR-II Peptide, TbetaR-II Peptide, TbetaRII Peptide, TGFBR2 Peptide, TBETA-RII Peptide, TGFBRII Peptide, TGF-beta 2 Peptide, Tgfbr2T Peptide, cb537 Peptide, tgfbr2 Peptide, wu:fj05c10 Peptide, zgc:110498 Peptide, transforming growth factor beta receptor 2 Peptide, transforming growth factor, beta receptor II Peptide, transforming growth factor, beta receptor 2 Peptide, transforming growth factor beta receptor 2b Peptide, TGFBR2 Peptide, Tgfbr2 Peptide, tgfbr2b Peptide
- Sujet
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TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in its gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.This gene is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It encodes a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: HNPCC6, MFS2, RIIC, Tbeta, AAT3, FAA3, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII
Protein Interaction Partner: FLI1,ARHGEF6,ARHGEF7,CLU,KCNK18,OSR1,PAK1,PML,PPP1CA,SCRIB,SMAD3,SMAD4,TGFB1,TGFB3,TGFBR1,TGFBR2,TSSK1B,ACVRL1,AP2B1,ARHGEF6,ARHGEF7,CCNB1,CCNB2,CD44,CDK1,CLU,CTNNB1,DAB2,DAXX,EIF3I,ENG,KCNK18,OSR1,PAK1,PIK3R1,PIK3R2,PML,SMAD3,SMAD4,SMAD7,SNX6,STRAP,TCTEX1D4,TGFB1,TGFB1I1,TGFB2,TGFB3,TGFBR1,TGFBR2,TGFBR3,TGFBRAP1,TRAP1,TSSK1B,ZFYVE9,ACVR1,AP2B1,CCNB1,CCNB2,CLU,CTNNB1,DAB2,ENG,HSP90AA1,PIK3R1,PIK3R2,SMAD7,SMURF2,SNX6,STRAP,TGFB1,TGFB2,TGFB3,TGFBR1,TGFBR3,UBC
Protein Size: 567 - Poids moléculaire
- 62 kDa
- ID gène
- 7048
- NCBI Accession
- NM_003242, NP_003233
- UniProt
- P37173
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