Toll-Like Receptor 5 (TLR5) (N-Term) Peptide
TLR5
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits TLR5
- TLR5 (Toll-Like Receptor 5 (TLR5))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-TLR5 antibody (Catalog #: ARP31753_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- TLR5 (Toll-Like Receptor 5 (TLR5))
- Synonymes
- SLEB1 Peptide, TIL3 Peptide, TLR-5 Peptide, sleb1 Peptide, til3 Peptide, tlr-5 Peptide, tlr5 Peptide, toll like receptor 5 Peptide, toll-like receptor 5 Peptide, toll like receptor 5 L homeolog Peptide, toll-like receptor 5b Peptide, TLR5 Peptide, Tlr5 Peptide, tlr5.L Peptide, tlr-5 Peptide, tlr5b Peptide
- Sujet
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TLR5 participates in the innate immune response to microbial agents. It mediates detection of bacterial flagellins. TLR5 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ10052, MGC126430, MGC126431, SLEB1, TIL3
Protein Interaction Partner: MYD88,RNF216,SIGIRR,TLR1,TLR4,MYD88,RNF216
Protein Size: 858 - Poids moléculaire
- 98 kDa
- ID gène
- 7100
- NCBI Accession
- NM_003268, NP_003259
- UniProt
- O60602
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