TNFRSF1A-Associated Via Death Domain (TRADD) (Middle Region) Peptide
TRADD
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits TRADD
- TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))
- Protein Region
- Middle Region
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-TRADD antibody (Catalog #: AVARP02012_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))
- Synonymes
- TRADD Peptide, Hs.89862 Peptide, 9130005N23Rik Peptide, AA930854 Peptide, wu:fc59e02 Peptide, zgc:103556 Peptide, tradd Peptide, TNFRSF1A associated via death domain Peptide, conjugal transfer protein D Peptide, TNFRSF1A-associated via death domain Peptide, TNFRSF1A-associated via death domain L homeolog Peptide, tnfrsf1a-associated via death domain Peptide, TRADD Peptide, traDd Peptide, Tradd Peptide, tradd.L Peptide, tradd Peptide
- Sujet
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TRADD is the adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: Hs.89862, MGC11078
Protein Interaction Partner: FADD,FADD,KRT14,KRT18,NGFR,TNFRSF1A,TNFRSF1A,TRAF2,BCL10,BIRC3,CEP110,DAPK1,FADD,FAS,HIPK2,KRT14,KRT18,NGFR,PPP2R1A,RIPK1,STAT1,TNFRSF10A,TNFRSF10B,TNFRSF1A,TNFRSF21,TNFRSF25,TRADD,TRAF1,TRAF2,TRAF3,TRPC4AP,BCL10,CASP8,CAV1,FADD,FADD,HIPK2,KRT18,NGFR,NOL3,RIPK1,STAT1,TNF,TNFRSF10A,TNFRSF10B,TNFRSF1A,TNFRSF1A,TNFRSF21,TNFRSF25,TRADD,TRAF1,TRAF2,TRAF2,TRPC4AP
Protein Size: 312 - Poids moléculaire
- 34 kDa
- ID gène
- 8717
- NCBI Accession
- NM_003789, NP_003780
- UniProt
- Q15628
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