Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) (Middle Region) Peptide
TRPV4
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
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- Antigène Tous les produits TRPV4
- TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))
- Protein Region
- Middle Region
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-TRPV4 antibody (Catalog #: ARP35330_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- TRPV4 (Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4))
- Synonymes
- wu:fp52e02 Peptide, CMT2C Peptide, HMSN2C Peptide, OTRPC4 Peptide, SMAL Peptide, SPSMA Peptide, SSQTL1 Peptide, TRP12 Peptide, VRL2 Peptide, VROAC Peptide, 0610033B08Rik Peptide, Trp12 Peptide, VR-OAC Peptide, VRL-2 Peptide, Otrpc4 Peptide, Vroac Peptide, transient receptor potential cation channel, subfamily V, member 4 Peptide, transient receptor potential cation channel subfamily V member 4 Peptide, trpv4 Peptide, TRPV4 Peptide, Trpv4 Peptide
- Sujet
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TRPV4 is a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation of TRPV4 by exposure to hypotonicity within the physiological range exhibits an outward rectification. TRPV4 also activated by low pH , citrate and phorbol esters and increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3) This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: OTRPC4, TRP12, VR-OAC, VRL-2, VRL2, VROAC, CMT2C, SPSMA, HMSN2C, SSQTL1
Protein Interaction Partner: CALM1,FYN,HCK,ITCH,LCK,LYN,MAP7,PACSIN1,PACSIN2,PACSIN3,SRC,TRPV4,YES1,FYN,HCK,LCK,LYN,MAP7,OS9,PACS1,SRC,UBC,YES1
Protein Size: 811 - Poids moléculaire
- 91 kDa
- ID gène
- 59341
- NCBI Accession
- NM_147204, NP_671737
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