Vitamin D Receptor (VDR) (N-Term) Peptide
VDR
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits Vitamin D Receptor (VDR)
- Vitamin D Receptor (VDR)
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-VDR antibody (Catalog #: P100895_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Vitamin D Receptor (VDR) peptide
VDR Reactivité: Humain, Souris, Rat, Chien Hôte: Synthetic BP, Imm
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- Vitamin D Receptor (VDR)
- Synonymes
- vdrbeta Peptide, vdr0 Peptide, LOC100136219 Peptide, NR1I1-B Peptide, gb:dq017633 Peptide, vdr-b Peptide, Ci-VDR-b Peptide, VDR Peptide, LOC100221284 Peptide, vdr-A Peptide, xVDR Peptide, Nr1i1 Peptide, vdr Peptide, NR1I1 Peptide, PPP1R163 Peptide, vitamin D (1,25- dihydroxyvitamin D3) receptor Peptide, vitamin D receptor Peptide, vitamin D3 receptor A Peptide, vitamin D receptor b Peptide, nuclear receptor VDR-b Peptide, vitamin D (1,25- dihydroxyvitamin D3) receptor L homeolog Peptide, vitamin D (1,25-dihydroxyvitamin D3) receptor Peptide, vitamin D receptor a Peptide, vdr Peptide, vdr0 Peptide, VDR Peptide, LOC100136219 Peptide, vdrb Peptide, vdr-b Peptide, vdr.L Peptide, Vdr Peptide, vdra Peptide
- Classe de substances
- Chemical
- Sujet
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VDR is the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Thus, alternative splicing results and multiple transcript variants encoding the same protein appears. This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: NR1I1
Protein Interaction Partner: CDK7,GTF2B,KDM5A,NCOA1,NCOA2,NCOA3,RXRA,SMAD3,ACVR1,BAG1,CCND3,CDK7,CREBBP,CSNK2A1,FGR,GABARAPL1,GABARAPL2,GTF2B,HMGN3,HR,JUN,KDM5A,MED1,NCOA1,NCOA2,NCOA6,NR0B2,NR1H2,NRIP1,PPP1CA,PPP2CA,PSMC5,RXRA,RXRB,RXRG,SMAD3,SNW1,SNW1,STAT1,TDG,TRIM24,VDR,ZBTB16,BAG1,BAZ1B,FOS,JUN,KDM5A,MED1,MED12,MED13,MED14,MED16,MED21,MED24,MED6,NCOA2,NCOA3,NCOR1,NCOR2,Ncoa2,POU1F1,POU2F1,RB1,RUNX1,RUNX1T1,RXRA,SMARCA4,SNW1,STAT1,TDG,THRAP3,TRRAP,VDR,ZBTB16
Protein Size: 427 - Poids moléculaire
- 48 kDa
- ID gène
- 7421
- NCBI Accession
- NM_000376, NP_000367
- UniProt
- P11473
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