Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

POLH Produits

(Polymerase (DNA Directed), eta (POLH))

Catégories

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA\; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008].

antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.

Catégories POLH en vedette

POLH Anticorps

High quality antibodies with extensive validation data.

POLH Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

POLH recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
N° du produit ABIN7150247
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB, ELISA, IHC
Validations
  • (3)
N° du produit ABIN7252888
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IF
Validations
  • (3)
N° du produit ABIN7259837
Quantité 200 μL
Fiche technique Fiche technique

POLH recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1315646
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
N° du produit ABIN3094678
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
N° du produit ABIN3137297
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits POLH

Barkley, Palle, Durando, Day, Gurkar, Kakusho, Li, Masai, Vaziri: "c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks." dans: Molecular biology of the cell, Vol. 23, Issue 10, pp. 1943-54, (2012) (PubMed).

Day, Palle, Barkley, Kakusho, Zou, Tateishi, Verreault, Masai, Vaziri: "Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication." dans: The Journal of cell biology, Vol. 191, Issue 5, pp. 953-66, (2010) (PubMed).

Parker, Bielen, Dikic, Ulrich: "Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae." dans: Nucleic acids research, Vol. 35, Issue 3, pp. 881-9, (2007) (PubMed).

Skoneczna, McIntyre, Skoneczny, Policinska, Sledziewska-Gojska: "Polymerase eta is a short-lived, proteasomally degraded protein that is temporarily stabilized following UV irradiation in Saccharomyces cerevisiae." dans: Journal of molecular biology, Vol. 366, Issue 4, pp. 1074-86, (2007) (PubMed).

Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: "The DNA sequence and analysis of human chromosome 6. ..." dans: Nature, Vol. 425, Issue 6960, pp. 805-11, (2003) (PubMed).

Glick, Vigna, Loeb: "Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions." dans: The EMBO journal, Vol. 20, Issue 24, pp. 7303-12, (2001) (PubMed).

Yuasa, Masutani, Eki, Hanaoka: "Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene." dans: Oncogene, Vol. 19, Issue 41, pp. 4721-8, (2000) (PubMed).

Masutani, Kusumoto, Yamada, Dohmae, Yokoi, Yuasa, Araki, Iwai, Takio, Hanaoka: "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta." dans: Nature, Vol. 399, Issue 6737, pp. 700-4, (1999) (PubMed).

Johnson, Kondratick, Prakash, Prakash: "hRAD30 mutations in the variant form of xeroderma pigmentosum." dans: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 263-5, (1999) (PubMed).

Synonymes et noms alternatifs relatifs à POLH

polymerase (DNA directed), eta S homeolog (polh.S), DNA polymerase eta (POLH), polymerase (DNA directed), eta (polh), DNA polymerase eta (Tb10.70.6190), putative DNA polymerase eta (LINJ_21_0690), polymerase (DNA directed), eta (Polh), DNA polymerase eta (LOC100443019), DNA polymerase eta (polh), DNA polymerase eta (Polh), polymerase (DNA directed), eta (RAD 30 related) (Polh), fc50a12, POLH, RAD30, RAD30A, wu:fc50a12, XP-V, XPV, zgc:136881, zgc:152642

Protein level used designations for POLH

  • DNA-directed DNA polymerase eta
  • DNA polymerase eta
  • polymerase (DNA directed), eta
  • DNA polymerase eta-like
  • polymerase eta
  • RAD30 homolog A
  • xeroderma pigmentosum variant type protein
  • polymerase (DNA directed), eta (RAD 30 related)
  • xeroderma pigmentosum variant type protein homolog
Vous êtes ici:
Support technique