POLI Produits
(Polymerase (DNA Directed) iota (POLI))
Catégories
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (By similarity).
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Catégories POLI en vedette
POLI Anticorps
High quality antibodies with extensive validation data.
POLI Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
POLI recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
- (5)
N° du produit
ABIN564869
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
N° du produit
ABIN6264338
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
N° du produit
ABIN7150251
Quantité
100 μg
Fiche technique
Fiche technique
POLI recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6203766
Quantité
96 tests
Fiche technique
Fiche technique
POLI recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124512
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1315648
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1315650
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits POLI
: "DNA polymerase ι is acetylated in response to SN2 alkylating agents." dans: Scientific reports, Vol. 9, Issue 1, pp. 4789, (2019) (PubMed).: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." dans: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).
: "Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication." dans: Molecular and cellular biology, Vol. 35, Issue 4, pp. 699-715, (2015) (PubMed).
: "Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin." dans: Nature communications, Vol. 5, pp. 5437, (2014) (PubMed).
: "DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity." dans: Nucleic acids research, Vol. 40, Issue 1, pp. 170-80, (2011) (PubMed).
: "Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Replication in HeLa Cells: A Comprehensive Study Using Alkaline Sucrose Density Gradient Sedimentation." dans: Journal of nucleic acids, Vol. 2010, pp. 750296, (2010) (PubMed).
: "DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 28, pp. 11552-7, (2009) (PubMed).
: "Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations." dans: Cancer research, Vol. 67, Issue 7, pp. 3018-26, (2007) (PubMed).
: "The role of DNA polymerase iota in UV mutational spectra." dans: Mutation research, Vol. 599, Issue 1-2, pp. 58-65, (2006) (PubMed).
: "Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template." dans: The EMBO journal, Vol. 20, Issue 11, pp. 2914-22, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à POLI
DNA polymerase iota (POLI), polymerase (DNA directed) iota (poli), DNA polymerase iota (LOC551219), DNA polymerase iota (AFUA_4G11140), DNA polymerase iota (LOC5568276), polymerase (DNA directed) iota (Pol-iota), polymerase (DNA directed), iota (Poli), DNA polymerase iota (Poli), GB12093, NV16187, poli, RAD3OB, RAD30B, Rad30b, wu:fc27h11, zgc:110185Protein level used designations for POLI
- DNA polymerase iota
- polymerase (DNA directed) iota
- DNA polymerase iota-like
- RAD30 homolog B
- eta2
- polymerase (DNA-directed), iota
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