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POLK Produits

(Polymerase (DNA Directed) kappa (POLK))

Catégories

External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM, Jan 2010].

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Catégories POLK en vedette

POLK Anticorps

High quality antibodies with extensive validation data.

POLK Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

POLK recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IF, IHC (p), RNAi
Validations
  • (1)
  • (7)
N° du produit ABIN565606
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IF
Validations
  • (3)
N° du produit ABIN949322
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application IF
Validations
  • (2)
N° du produit ABIN7261966
Quantité 200 μL
Fiche technique Fiche technique

POLK recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6206770
Quantité 96 tests
Fiche technique Fiche technique

POLK recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (3)
  • (3)
N° du produit ABIN2452172
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1315652
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7124513
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits POLK

Xiang, Laurent, Hsu, Nachtergaele, Lu, Sheng, Xu, Chen, Ouyang, Wang, Ling, Hsu, Zou, Jambhekar, He, Shi: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." dans: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).

Sekimoto, Oda, Kurashima, Hanaoka, Yamashita: "Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication." dans: Molecular and cellular biology, Vol. 35, Issue 4, pp. 699-715, (2015) (PubMed).

Uljon, Johnson, Edwards, Prakash, Prakash, Aggarwal: "Crystal structure of the catalytic core of human DNA polymerase kappa." dans: Structure (London, England : 1993), Vol. 12, Issue 8, pp. 1395-404, (2004) (PubMed).

Yasui, Suzuki, Miller, Matsuda, Matsui, Shibutani: "Translesion synthesis past 2'-deoxyxanthosine, a nitric oxide-derived DNA adduct, by mammalian DNA polymerases." dans: Journal of molecular biology, Vol. 344, Issue 3, pp. 665-74, (2004) (PubMed).

Haracska, Prakash, Prakash: "A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair." dans: Genes & development, Vol. 17, Issue 22, pp. 2777-85, (2003) (PubMed).

Ohashi, Bebenek, Matsuda, Feaver, Gerlach, Friedberg, Ohmori, Kunkel: "Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene." dans: The Journal of biological chemistry, Vol. 275, Issue 50, pp. 39678-84, (2001) (PubMed).

Ohashi, Ogi, Kusumoto, Iwai, Masutani, Hanaoka, Ohmori: "Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa." dans: Genes & development, Vol. 14, Issue 13, pp. 1589-94, (2000) (PubMed).

Czerkawski, Blaxter, Wainman: "The metabolism of oleic, linoleic and linolenic acids by sheep with reference to their effects on methane production." dans: The British journal of nutrition, Vol. 20, Issue 2, pp. 349-62 (PubMed).

Synonymes et noms alternatifs relatifs à POLK

DNA polymerase kappa (POLK), DNA polymerase kappa (Polk), polymerase (DNA directed) kappa (polk), DNA polymerase kappa (Tb11.01.0080), DNA polymerase kappa (Tb11.01.0010), DNA polymerase kappa (Tb11.01.0020), DNA polymerase kappa (Tb11.01.0030), DNA polymerase kappa (Tb11.01.0040), DNA polymerase kappa (Tb11.01.0050), DNA polymerase kappa (Tb11.12.0001), DNA polymerase kappa (Tb11.12.0002), DNA polymerase kappa (Tb11.12.0003), polymerase (DNA directed), kappa (Polk), polymerase (DNA directed) kappa L homeolog (polk.L), DNA polymerase kappa (polk-1), DINB1, Dinb1, DINP, POLK, POLQ, si:ch211-254o18.3

Protein level used designations for POLK

  • DNA polymerase kappa
  • DNA-directed DNA polymerase kappa
  • polymerase (DNA directed) kappa
  • DNA polymerase kappa-like
  • DINB protein
  • DINP
  • DNA damage-inducible protein b
  • DinB homolog 1
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