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The hearts of Rad21-depleted animals were smaller, often failed to loop, and functioned less efficiently than size-matched controls
RAD21a suppression led to delayed intestinal transit and greatly reduced numbers of enteric neurons, similar to patients with chronic intestinal pseudo-o (Montrer RUNX1 Protéines)bstructio (Montrer APOB Protéines)n.
Cohesin is a protein complex essential for sister chromatid cohesion and DNA repair that also appears to be essential for normal development through as yet unknown mechanisms.
This study together with previous reports suggests incomplete penetrance associated with RAD21 variants and these individuals may therefore be underdiagnosed.
Data indicate that RAD21 plays an important role in cellular senescence breast cancer cells, mainly through RB1 (Montrer RB1 Protéines) pathway activation via c-Myc (Montrer MYC Protéines) downregulation.
Reduced RAD21 destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability.
found well-positioned CTCF and RAD21 peaks approximately 60-80 bp upstream of the TSS in the unidirectional genes. The peak heights were related to the amount of antisense transcription. Results provide insights into the distribution of histone modifications at promoters and suggest a novel role of CTCF and cohesin as regulators of transcriptional direction.
Studied the role of looping in large-scale (supra Mb) folding of human chromosomes by knocking down the gene that codes for CTCF and the one coding for Rad21, an essential subunit of cohesin.
Elevated RAD21 expression tracks with reactivation of L1 expression in human sporadic colorectal cancer.
Some patients with chronic intestinal pseudo-obstruction carry mutations in RAD21 that disrupt the ability of its product to regulate genes such as RUNX1 (Montrer RUNX1 Protéines) and APOB (Montrer APOB Protéines).
CTCF (Montrer CTCF Protéines) and Rad21 act as host cell restriction factors for Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by modulating viral gene transcription.
cohesin's proposed DNA exit gate is formed by interactions between Scc1 (Montrer PTPRJ Protéines) and the coiled-coil region of Smc3 (Montrer SMC3 Protéines).
Cross-sectional deep-sequencing analysis for clonal hierarchy demonstrated STAG2 (Montrer STAG2 Protéines), SMC3 (Montrer SMC3 Protéines), and RAD21 mutations to be ancestral in 18%, 18%, and 47% of cases, respectively, and each expanded to clonal dominance concordant with disease transformation
The results demonstrate that the zygotic genome folds into loops and domains that critically depend on Scc1-cohesin and that are regulated in size and linear density by Wapl.
n keratinocytes, the promoter-enhancer anchoring regions in the gene-rich transcriptionally active TADs are enriched for the binding of chromatin architectural proteins CTCF (Montrer CTCF Protéines), Rad21 and chromatin remodeler Brg1 (Montrer SMARCA4 Protéines). In contrast to gene-rich TADs, gene-poor TADs show preferential spatial contacts with each other, do not contain active enhancers and show decreased binding of CTCF (Montrer CTCF Protéines), Rad21 and Brg1 (Montrer SMARCA4 Protéines) in keratinocytes
the cohesin complex regulates PRC2 targeting to silence Hoxa7 and Hoxa9 and negatively regulate self-renewal. Our studies identify a novel epigenetic mechanism underlying leukemogenesis in AML patients with cohesin mutations.
Knockdown of Rad21 reduces expression of the constitutive, biallelically expressed Pcdhalpha isoforms alphac1 and alphac2.
show that spermatocytes from mice lacking the two meiosis-specific cohesin subunits RAD21L (Montrer RAD21L1 Protéines) and REC8 (Montrer REC8 Protéines) were unable to initiate RAD51 (Montrer RAD51 Protéines)- but not DMC1 (Montrer DMC1 Protéines)-mediated double-strand break repair
findings firmly establish a cell-division-independent role for cohesin in Tcra locus rearrangement and provide a comprehensive account of the mechanisms by which cohesin enables cellular differentiation
knock-down of RAD21 causes expression changes that are similar to expression changes after Nanog (Montrer NANOG Protéines) depletion, demonstrating the functional relevance of the RAD21--pluripotency transcriptional network association
The signal of RAD21 was prominent in somatic cells outside the seminiferous tubules or in spermatogonia, and was also detected in some spermatocytes localizing away from the basement membrane.
Rad21 is a DNA-damage response gene that markedly affects animal and cell survival
a cohesin complex containing Rad21 and STAG2 cooperates with a STAG3-specific complex to maintain sister chromatid cohesion during the diplotene stage of meiosis
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.
double-strand-break repair protein rad21 homolog
, RAD21 homolog (S. pombe)
, SCC1 homolog
, nuclear matrix protein 1
, protein involved in DNA double-strand break repair
, sister chromatid cohesion 1
, pokeweed agglutinin-binding protein 29
, RAD21 homolog