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anti-Human Urocortin Anticorps:
anti-Rat (Rattus) Urocortin Anticorps:
anti-Mouse (Murine) Urocortin Anticorps:
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These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 (Montrer CRHR1 Anticorps) and CRHR2 (Montrer CRHR2 Anticorps) and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
Results describe the distribution of urotensin I, UIIalpha and UIIbeta mRNAs in different organs and the cellular localization of the three mRNAs in the spinal cord by in situ hybridization (ISH (Montrer ANTXR2 Anticorps)) histochemistry.
Study found reduced miR (Montrer MLXIP Anticorps)-326 levels concomitant with elevated Ucn1 levels in Edinger-Westphal nucleus (EWcp) of depressed suicide completers and in the EWcp of depressed rats. In fully recovered rats, both serum and EWcp miR (Montrer MLXIP Anticorps)-326 levels rebounded to nonstressed levels. While downregulation of miR (Montrer MLXIP Anticorps)-326 levels in primary midbrain neurons enhanced Ucn1 expression levels, miR (Montrer MLXIP Anticorps)-326 overexpression selectively reduced its levels.
In deep infiltrating endometriotic lesions, CRH (Montrer CRH Anticorps), Ucn and CRH-R2 (Montrer CRHR2 Anticorps) mRNA levels were significantly higher than in ovarian endometrioma.
UCN I is secreted from human glioblastoma cells by exocytosis through constitutive secretory granules.
Findings identify Ucn as a potential mediator that inhibits TGFbeta1 (Montrer TGFB1 Anticorps) oncogenic signaling in breast neoplasm.
In women with adnexal endometrioma versus teratoma (Montrer DND1 Anticorps), the medians were 105.31 pg/mL versus 120.84 pg/mL for urocortin, 7.16 pg/mL versus 9.13 pg/mL for leptin (Montrer LEP Anticorps) and 584.33 pg/mL versus 657.82 pg/mL for ghrelin (Montrer GHRL Anticorps) (p > 0.05), respectively.
Ucn1 prevents the development of atherosclerosis by suppressing EC inflammatory response and proliferation, macrophage foam cell formation, and VSMC migration and proliferation
These data suggest that UVB-stimulated Ucn1 contributes to TRP1 (Montrer PRSS1 Anticorps) production via the transcription of both Nurr-1 (Montrer NR4A2 Anticorps) and Nur77 (Montrer NR4A1 Anticorps). Ucn1, produced in melanoma cells, acts on melanoma cells themselves in an autocrine manner.
Production of CRF (Montrer CRH Anticorps) and UCN1 in human dendritic cells is strongly augmented by commensal intestinal bacteria.
Cardioplegic arrest failed to induce cardiac myocyte overexpression of urocortin in diabetic hearts.
Urocortin expression inversely correlates with higher tumor grade and advanced tumor stage in gastric adenocarcinomas.
Genetic deletion of Ucn1 reduced high levels of intake and preference across 2 weeks of continuous access drinking when alcohol concentrations were increased from 10 to 20 to 40%. Ucn1 deletion did not alter low-level drinking when the alcohol concentration remained at 10%.
Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus
it is shown that CRH (Montrer CRH Anticorps) and UCN upregulate galectin-1 (Montrer LGALS1 Anticorps) expression in Ishikawa cell line and macrophages and this effect is mediated through CRHR1 (Montrer CRHR1 Anticorps).
This study aims to investigate the cellular localization of CRF (Montrer CRH Anticorps) and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
CNTF (Montrer CNTF Anticorps) activates hypothalamic urocortin 1-expressing neurons both in vitro and in vivo.
The absence of the CB1 (Montrer CNR1 Anticorps) receptor alters the Ucn1 mRNA and peptide levels in Edinger-Westphal nucleus neurones, concomitant with an augmented stress response and increased anxiety-like behaviour.
EWcp-Ucn1 neurons play an important role in EtOH intake, preference, and reward.
CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise
Data suggest that UCN regulates osteoclast resorption by suppressing osteoclast maturation/function via suppression of constitutively active cation channel (Montrer TRPV1 Anticorps) (CRFR2beta (Montrer CRHR2 Anticorps)) with properties of canonical transient receptor potential 1 (TRPC1 (Montrer TRPC1 Anticorps)) channel.
Ucn1 gene was downregulated in 5-HTT (Montrer SLC6A4 Anticorps) KO and upregulated in 5-HTT (Montrer SLC6A4 Anticorps) TG mice which exhibit opposite changes in anxiety-related behavior; findings suggesti this peptide can be involved in behavioral changes observed in 5-HTT (Montrer SLC6A4 Anticorps) mutant mice
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.
, urocortin, preproprotein