ACVR2B Protein (AA 19-134) (His tag)

N° du produit ABIN1095963

Détail du produit

Antigène: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Type de proteíne: Recombinant

Attributs du protein: AA 19-134

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette ACVR2B protéine est marqué à la His tag.

Fonction: Recombinant Human Activin Receptor 2B/Activin RIIB/ACVR2B (C-6His)

Séquence: SGRGEAETRE CIYYNANWEL ERTNQSGLER CEGEQDKRLH CYASWRNSSG TIELVKKGCW LDDFNCYDRQ ECVATEENPQ VYFCCCEGNF CNERFTHLPE AGGPEVTYEP PPTAPTVDHH HHHH

Attributs du produit: Recombinant Human Activin Receptor Type IIB/ACVR2B is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Ser19-Thr134) of Human ACVR2B fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 3 months

Détail du antigène

Antigène: ACVR2B (Activin A Receptor, Type IIB (ACVR2B))

Abstract: ACVR2B Produits

Synonymes: ACVR2B Protein, XAR1 Protein, actr-iib Protein, actriib Protein, ACTRIIB Protein, ActR-IIB Protein, HTX4 Protein, ActRIIB Protein, actr2b Protein, actrIIb Protein, wu:fj97d11 Protein, activin A receptor type 2B Protein, activin A receptor type 2B L homeolog Protein, activin A receptor type 2Ba Protein, activin receptor IIB Protein, ACVR2B Protein, acvr2b Protein, acvr2b.L Protein, Acvr2b Protein, acvr2ba Protein

Sub Type: Fusionprotein

Sujet: Activin proteins that belong to the transforming growth factor-beta (TGF-beta) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities.
Alternative Names: Activin Receptor Type-2B, Activin Receptor Type IIB, ACTR-IIB, ACVR2B

Poids moléculaire: 14.37 kDa

UniProt: Q13705

Pathways: Hormone Transport, Cancer Immune Checkpoints