PROCR Protein (AA 18-210) (His tag)

N° du produit ABIN1096576

Détail du produit

Antigène: PROCR (Protein C Receptor, Endothelial (PROCR))

Type de proteíne: Recombinant

Attributs du protein: AA 18-210

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette PROCR protéine est marqué à la His tag.

Fonction: Recombinant Human Endothelial Protein C Receptor/EPCR/PROCR/CD201 (C-6His)

Séquence: SQDASDGLQR LHMLQISYFR DPYHVWYQGN ASLGGHLTHV LEGPDTNTTI IQLQPLQEPE SWARTQSGLQ SYLLQFHGLV RLVHQERTLA FPLTIRCFLG CELPPEGSRA HVFFEVAVNG SSFVSFRPER ALWQADTQVT SGVVTFTLQQ LNAYNRTRYE LREFLEDTCV QYVQKHISAE NTKGSQTSRS YTSVDHHHHH H

Attributs du produit: Recombinant Human Endothelial Protein C Receptor/EPCR is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Ser18-Ser210) of Human EPCR fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 3 months

Détail du antigène

Antigène: PROCR (Protein C Receptor, Endothelial (PROCR))

Autre désignation: epcr (PROCR Produits)

Synonymes: PROCR Protein, CCCA Protein, CCD41 Protein, EPCR Protein, AI325044 Protein, Ccca Protein, Ccd41 Protein, Epcr Protein, protein C receptor Protein, protein C receptor, endothelial Protein, PROCR Protein, Procr Protein

Sub Type: Fusionprotein

Sujet: Endothelial Protein C Receptor (EPCR) is a Vitamin K-dependent Serine Protease that plays a major role in blood coagulation. Binding of Protein C to EPCR leads to the proteolytic activation of PAR1 (Protease-Activated Receptor 1) on endothelial cells and subsequent up-regulation of Protein C-induced genes. EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology. EPCR plays an important role in augmenting Protein C activation by the Thrombin-Thrombomodulin complex and in regulating blood coagulation and inflammation. EPCR is found primarily on endothelial cells. Deletion of EPCR function results in embryonic death, at least in part due to placental thrombosis.
Alternative Names: Endothelial Protein C Receptor, Activated Protein C Receptor, APC Receptor, Endothelial Cell Protein C Receptor, CD201, PROCR, EPCR

Poids moléculaire: 23.06 kDa

UniProt: Q9UNN8