Kininogen Protein (KNG) (AA 19-427) (His tag)

N° du produit ABIN1097035

Détail du produit

Antigène: Kininogen (KNG)

Type de proteíne: Recombinant

Attributs du protein: AA 19-427

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette Kininogen protéine est marqué à la His tag.

Fonction: Recombinant Human Kininogen-1/KNG1 (C-6His)

Séquence: QESQSEEIDC NDKDLFKAVD AALKKYNSQN QSNNQFVLYR ITEATKTVGS DTFYSFKYEI KEGDCPVQSG KTWQDCEYKD AAKAATGECT ATVGKRSSTK FSVATQTCQI TPAEGPVVTA QYDCLGCVHP ISTQSPDLEP ILRHGIQYFN NNTQHSSLFM LNEVKRAQRQ VVAGLNFRMT YSIVQTNCSK ENFLFLTPDC KSLWNGDTGE CTDNAYIDIQ LRIASFSQNC DIYPGKDFVQ PPTKICVGCP RDIPTNSPEL EETLTHTITK LNAENNATFY FKIDNVKKAR VQVVAGKKYF IDFVARETTC SKESNEELTE SCETKKLGQS LDCNAEVYVV PWEKKIYPTV NCQPLGMISL MKRPPGFSPF RSSRIGEIKE ETTSHLRSCE YKGRPPKAGA EPASEREVSL DHHHHHH

Attributs du produit: Recombinant Human Kininogen-1/KNG1 produced by transfected human cells is a secreted protein with sequence (Gln19-Ser427) of human KNG1 fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Hac-NaAC, 150 mM NaCl, pH 4.0.

Conseil sur la manipulation: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Stock: 4 °C/-20 °C/-80 °C

Stockage commentaire: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 3 months

Détail du antigène

Antigène: Kininogen (KNG)

Autre désignation: kininogen (KNG Produits)

Synonymes: kininogen Protein, kininogen 1 Protein, Kng1 Protein

Sub Type: Fusionprotein

Sujet: Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. The active peptide bradykinin that is released from Kininogen-1 shows a variety of physiological effects: influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis, decrease in blood glucose level. It is a mediator of inflammation and causes increase in vascular permeability, stimulation of nociceptors release of other mediators of inflammation. It has a cardioprotective effect. LMW-kininogen inhibits the aggregation of thrombocytes and doesn’t involved in blood clotting.
Alternative Names: Kininogen-1, lpha-2-Thiol Proteinase Inhibitor, Fitzgerald Factor, High Molecular Weight Kininogen, HMWK, Williams-Fitzgerald-Flaujeac Factor, KNG1, BDK, KNG

Poids moléculaire: 46.89 kDa

UniProt: P01042